| IED ID | IndEnz0002002799 |
| Enzyme Type ID | protease002799 |
| Protein Name |
Integrin alpha-1 CD49 antigen-like family member A Laminin and collagen receptor VLA-1 CD antigen CD49a |
| Gene Name | ITGA1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK |
| Enzyme Length | 1179 |
| Uniprot Accession Number | P56199 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 498..506; /evidence=ECO:0000255; CA_BIND 580..588; /evidence=ECO:0000255; CA_BIND 642..650; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (5); Calcium binding (3); Chain (1); Disulfide bond (7); Domain (1); Glycosylation (26); Helix (12); Motif (1); Natural variant (4); Repeat (7); Sequence conflict (3); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (2) |
| Keywords | 3D-structure;Calcium;Cell adhesion;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | P04512 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (2); X-ray crystallography (5) |
| Cross Reference PDB | 1PT6; 1QC5; 1QCY; 2L8S; 2M32; 4A0Q; 5HGJ; |
| Mapped Pubmed ID | 10713152; 11454259; 11457814; 11518510; 11572855; 11877061; 11937138; 12078857; 12423238; 12662928; 12694973; 12721290; 12879062; 15109703; 15132990; 15383545; 15485856; 15679046; 16043429; 16151532; 16412752; 16413178; 16472776; 16754661; 1697296; 17312461; 17377534; 17603494; 17669516; 17891451; 17931993; 17982677; 18048918; 18081024; 18269595; 18377961; 18454440; 18587047; 18813796; 1930128; 19397781; 19730683; 19780039; 19850917; 19913121; 20232313; 20436081; 20531279; 20628086; 20711500; 20802519; 21521694; 21647271; 21947080; 21965670; 22002573; 22030389; 22298882; 22698912; 22847004; 22919661; 23070086; 23284937; 23448258; 23646163; 24018042; 24124332; 24164540; 24187131; 2526655; 25550552; 25672754; 26096932; 26496610; 27294728; 27342747; 2764880; 27929375; 28318877; 28809852; 28855593; 28904065; 28952190; 29079572; 29440721; 29504106; 29761640; 29937357; 32753478; 32986180; 34566986; 34906278; 3780718; 8118028; 8344274; 9361014; 9367446; |
| Motif | MOTIF 1167..1171; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 130,848 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |