| IED ID | IndEnz0002002804 |
| Enzyme Type ID | protease002804 |
| Protein Name |
Integrin alpha-X CD11 antigen-like family member C Leukocyte adhesion glycoprotein p150,95 alpha chain Leukocyte adhesion receptor p150,95 CD antigen CD11c |
| Gene Name | Itgax |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MSCTWIAFLLLLGFVSCLGFNLDAEKLTHFHMDGAEFGHSVLQYDSSWVVVGAPKEIKATNQIGGLYKCGYHTGNCEPISLQVPPEAVNISLGLSLAAATNPSWLLACGPTVHHTCRENIYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGSGSISSTDFEKMLDFVKAVMSQLQRPSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLGSVRQLRGYTYTASAIKHVITELFTTQSGARQDATKVLIVITDGRKQGDNLSYDSVIPMAEAASIIRYAIGVGKAFYNEHSKQELKAIASMPSHEYVFSVENFDALKDIENQLKEKIFAIEGTETPSSSTFELEMSQEGFSAVFTPDGPVLGAVGSFSWSGGAFLYPSNMRPTFINMSQENEDMRDAYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRPKSEVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSVCPMPGVGSRWHCGTTLHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRISASQIPSRIQYFGQSLSGGQDLTRDGLVDLAVGSKGRVLLLRTRPILRVSPTVHFTPAEISRSVFECQEQVAPEQTLSDATVCLHIHESPKTQLGDLRSTVTFDLALDHGRLSTRAIFKETKTRALTRVKTLGLNKHCESVKLLLPACVEDSVTPITLRLNFSLVGVPISSLQNLQPMLAVDDQTYFTASLPFEKNCGADHICQDDLSVVFGFPDLKTLVVGSDLELNVDVTVSNDGEDSYGTTVTLFYPVGLSFRRVAEGQVFLRKKEDQQWQRRGQHSLHLMCDSTPDRSQGLWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVGSENNVPGTPKTTFQLELPVKYAVYTMISSHDQFTKYLNFSTSEKEKTSVVEHRFQVNNLGQRDVPVSINFWVPIELKGEAVWTVMVSHPQNPLTQCYRNRLKPTQFDLLTHMQKSPVLDCSIADCLHLRCDIPSLGILDELYFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVYSQLPGQEAFLRAQTKTVLEMYKVHNPVPLIVGSSVGGLLLLAIITAILYKAGFFKRQYKEMLEEANGQFVSDGTPTPQVAQ |
| Enzyme Length | 1169 |
| Uniprot Accession Number | Q9QXH4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 467..475; /evidence=ECO:0000250; CA_BIND 531..539; /evidence=ECO:0000250; CA_BIND 594..602; /evidence=ECO:0000250 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Calcium binding (3); Chain (1); Disulfide bond (10); Domain (1); Glycosylation (7); Metal binding (16); Motif (1); Repeat (7); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Calcium;Cell adhesion;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10330002; 10330270; 10648399; 11683172; 11937543; 12121661; 12466851; 12648490; 12801066; 1385153; 1431091; 14609575; 14643301; 14657281; 14990792; 15210787; 15585877; 15705807; 15899409; 16011799; 16051744; 16141072; 16239568; 16513945; 16524567; 16815646; 16920972; 17056703; 17277142; 17525267; 17540342; 17628549; 17916553; 17923504; 17923507; 18097035; 18516037; 18523307; 18566428; 18606692; 18641199; 18664530; 18667491; 18694997; 18832748; 18840360; 18984740; 19004989; 19015306; 19384874; 19428111; 19433759; 19454691; 19494277; 19499519; 19584156; 19620319; 19653277; 19723499; 19783990; 19910635; 19948830; 20069263; 20231692; 20308074; 20388633; 20404099; 20404167; 20465572; 20505139; 20581095; 20617552; 20659336; 20889973; 21267068; 21273385; 21427223; 21436315; 21464233; 21469133; 21593477; 21765910; 21775452; 21825019; 2185332; 22445076; 22454532; 22786774; 22815909; 22822029; 22844116; 22851746; 22882618; 22972929; 22990073; 23018460; 23146677; 23284905; 23357382; 23481504; 23521885; 23733880; 24129162; 24287621; 24458151; 24519489; 24594519; 24659690; 24743235; 25271254; 25322675; 25393502; 25416814; 25693634; 25714599; 25786178; 25963626; 26034175; 26062999; 26112011; 26242598; 26529256; 26626303; 26627460; 26628365; 27119555; 27146521; 27230858; 27425031; 27500496; 27638116; 28292891; 28338898; 28421248; 28440501; 28550204; 28557137; 28780965; 28963396; 29549257; 29636416; 29891680; 30571485; 30606613; 30766536; 31980640; 32444476; 32680956; 33086061; 33153107; 33351105; 33502012; 33542915; 33567267; 34764952; 7751620; 9053454; |
| Motif | MOTIF 1140..1144; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 129,151 |
| Kinetics | |
| Metal Binding | METAL 158; /note=Magnesium; /evidence=ECO:0000250; METAL 160; /note=Magnesium; /evidence=ECO:0000250; METAL 162; /note=Magnesium; /evidence=ECO:0000250; METAL 260; /note=Magnesium; /evidence=ECO:0000250; METAL 467; /note=Calcium 2; /evidence=ECO:0000250; METAL 469; /note=Calcium 2; /evidence=ECO:0000250; METAL 471; /note=Calcium 2; /evidence=ECO:0000250; METAL 473; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250; METAL 533; /note=Calcium 3; /evidence=ECO:0000250; METAL 535; /note=Calcium 3; /evidence=ECO:0000250; METAL 537; /note=Calcium 3; via carbonyl oxygen; /evidence=ECO:0000250; METAL 594; /note=Calcium 1; /evidence=ECO:0000250; METAL 596; /note=Calcium 1; /evidence=ECO:0000250; METAL 598; /note=Calcium 1; /evidence=ECO:0000250; METAL 600; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 602; /note=Calcium 1; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |