| IED ID | IndEnz0002002832 |
| Enzyme Type ID | protease002832 |
| Protein Name |
Pheromone-processing carboxypeptidase kex1 EC 3.4.16.6 Carboxypeptidase D |
| Gene Name | kex1 PMAA_045500 |
| Organism | Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Trichocomaceae Talaromyces Talaromyces sect. Talaromyces Talaromyces marneffei (Penicillium marneffei) Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Enzyme Sequence | MLGKALLLLLSSPICAWAQSAADYYVKSIPGQPDGPLLKMHAGHVEVDAETNGHLFFWHFQNRHIANRQRTILWLNGGPGCSSMDGALMEIGPYRVKDDHTLIYNNGSWDEFANLLFVDQPVGTGFSYVNTNSYLHDLDHVAAHMITFLEKWFAMFPEYESDDLYIAGESYAGQYIPHIARAIVERNKNIQRNQQHWPIKGLLIGNGWISPRDQYPANLQYAYAEGIVKEGTAIANELDGIEKSCDEQLNAPGAGDLVDIRQCESILNKLLDLTRTSDDQCINVYDIRLKDATCGNAWPPDLDQMTDYLRRADVGAALNLDNGKANGWTECNNQVTANFRMGHNGVPSIQLLPGLIESGVKVLLFSGDRDLICNHLGTESLIHNMKWSGGTGFETKPGVWAPRRGWTFEGEAAGYYQQARNLTYVLFYNASHMVPYDFPRRTRDMVDRFINVDIANIGGPPADSRLDGEKLPQTSVGNTTSSTSGTDQVDEAKLKDAEWKAYTKSGEAALIVVIIGVSVWGFFIWRARQRAARDGTSPTKKGYRAVYQDGVDNNSSTDGAGLLSRFRNQSNSNSSRDLEARDFDEAELDSLTPNLQNGHERDHYVIGEEDEDEDNDIGNGAKSSLH |
| Enzyme Length | 626 |
| Uniprot Accession Number | B6QQZ9 |
| Absorption | |
| Active Site | ACT_SITE 170; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 370; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 432; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6; |
| DNA Binding | |
| EC Number | 3.4.16.6 |
| Enzyme Function | FUNCTION: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (2); Glycosylation (4); Region (3); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Apoptosis;Carboxypeptidase;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 69,623 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |