| IED ID | IndEnz0002002911 |
| Enzyme Type ID | protease002911 |
| Protein Name |
Intracellular coagulation inhibitor 1 Limulus intracellular coagulation inhibitor 1 LICI-1 |
| Gene Name | |
| Organism | Tachypleus tridentatus (Japanese horseshoe crab) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Merostomata (horseshoe crabs) Xiphosura Limulidae Tachypleus Tachypleus tridentatus (Japanese horseshoe crab) |
| Enzyme Sequence | MKLGDWKFCLLLFQLMFLTNVCLSDLSFNPYKWPVNQLRRVIGAVKVTNTSNYFGFSLYENLNSNGNVFISPYSLASVMAMLYLGARGVTKNEMDLTLGYNSVNLNSEDLVLGFQQSLLLLNAESKEYQLETANSLMIQNTFNILDNYKRMLEDKFGANVQDVDFINKAELVQRYINAWVAFKTKNKIPILLNEPLKPETRLAFFNAVYFKGVWETKFDSALTRRATFYNNGYVPTQVPMMMLRGIFPFAYVSSLRSYVLELPYKGHEVSMLLLLPKDRNGISDLERDLSSSSLDSVTSNLREIGVLVTIPKFKLEETYEDDLKQSLESMGMTSLFSEANANLEGITGHRDLFVTKITHRTLIEVNEEGTEASGISSVVAGVRSGWKRPTFTADHPFVFFIRHNRSGIILFMGRVSQL |
| Enzyme Length | 418 |
| Uniprot Accession Number | Q27085 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor that specifically inhibits clotting factor C (PubMed:8276848). Does not inhibit clotting factor B or proclotting enzyme (PubMed:8276848). {ECO:0000269|PubMed:8276848}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (2); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Glycoprotein;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q27086}. Note=Localizes in the large granules of hemocytes (By similarity). Secreted in hemolymph in response to external stimuli (By similarity). {ECO:0000250|UniProtKB:Q27086}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:8276848}. |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000269|PubMed:8276848 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,523 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |