| IED ID | IndEnz0002002913 |
| Enzyme Type ID | protease002913 |
| Protein Name |
Lon protease homolog, mitochondrial 2 EC 3.4.21.53 |
| Gene Name | DDB_0217928 DDB_G0277307 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MGSPTHFGLFLISDAEREVHMEELKSQEASKSKPPSKPKSNFTTFSHGTPDLSKIHKVGMLATVCRTQGYFVLGGGPIIEITGVSNDHDNNNSNLVEITESKNDTSDSTTTTTTTPSTSITPITTPVVPQIPTSKYLKVSIEPHEYSELGDSLTVRALRLQLVKCIYSAINRYQDSSFAQHLKQICMLPIFKMDDSSLLNSIGPLCISSPSEYQKLLECKSLEEKLNMVLSMLVKKCEVFDFNFSIEKQLEEKTMAQQKKYFLTEQMKLIRKELGIDLDEKETIKNKFNSRWKEIAVMDKQILQVFKEEMDKLSSCESNSSEYNTSRNYLDWMTLLPWNVYTNDNFDISKVKEILDRDHYGLKDIKEMIQTFIAVGKLRGSIGGKVILLVGPPGTGKTSVGKSIANALGRQFHRISVGGLSDVSEIKGHRRTYVASMPGKIIQALKTVKTSNPVILIDEIDKISRSSQGDPNSALLEVLDPQQNKNFVDYYLDVPYDLSRVLFICTANDADSIPAPLLDRMEVMTLNGYIQSEQMEIAKRYLLPLVRKETGISEEQLQFTPEAIKKLCELYCREAGVRNLKKFIDKIFRKMAYKLSMGMEQSVIITPDNLEQYVGPIKYPSSRLFQKQKPGIVMGLGGSLIHIESALDRFTNGPTVTTTGSLGLVMRESIDISYSYVKDFLLKVDASNDYFLKNSIHIHAPDGSTQKDISSAGITIVSSLLSLATGKLVKPDLAMVGEVSLTGKVIGVSGIVEKIVLAKRESIKTIIIPKENKKQLEEIPDFIKEGIEIYLVDYYSDVYSIAFTNDSTIKPLIFNDNKENQNENENQSEVKSTIIQ |
| Enzyme Length | 836 |
| Uniprot Accession Number | Q550C8 |
| Absorption | |
| Active Site | ACT_SITE 711; /evidence=ECO:0000255|HAMAP-Rule:MF_03120; ACT_SITE 754; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 391..398; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Features | Active site (2); Chain (1); Compositional bias (1); Domain (2); Nucleotide binding (1); Region (2) |
| Keywords | ATP-binding;DNA-binding;Hydrolase;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 93,649 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |