| IED ID | IndEnz0002002918 |
| Enzyme Type ID | protease002918 |
| Protein Name |
Lon protease homolog, mitochondrial EC 3.4.21.53 |
| Gene Name | pim1 AFUA_2G11740 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MLRGQSLPWRAALHQTPRPTVLRPLLPFARNNGPVRSNLSISRLSRSPSLSPRAFSTSSIRRKEKPPSDEKEDSNLQEQKDPNEQKDSDRSPEGRRRSPDSTGREPGAPTSASGRRRDKVAGEKEQRGVEEDAKKENVSIEGKSDPTEDPSPIPVNGGGSSDTKSSASNGGNEDGGRKGKKGSGDRALQKPSVPEVYPQVMAIPIAKRPLFPGFYKAITIRDPNVATAIQEMMKRGQPYVGAFLFKDENADGDVIENLDDVYDVGVFAQITAAYPLRGEASGVTAVLYPHRRIKISSLLPPGEQSKAGNTEDKAPEKKGDVVASFEEGVAEPAPKDLYEPTSFLRKYPVSLVNVENLAEEPFDKKSAIIRAVTSEIVNVCKEIASLNPLFRDQISAFYTDQFPGNLSDEPAKLADFAAAVSAGELHEMQEVLEIMNIEERLPKALVVLKKELMNAQLQSKISKDVEAKIQKRQREYWLMEQMKGIKRELGIESDGKDKLVEKFKEKASKLAMPDAVKKVFDEEINKLAHLEPAASEFNVTRNYLDWLTQIPWGQKSVENFGIKHAMTVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVTDTIPRPLLDRMELIELSGYVADEKMAIAERYLAPAARELTGLKDVDVNLQKDAIEELIKSYARESGVRNLKKQIEKVYRKAAFKIVQDLGEEVLGEDKALTDEGKAAQEESKKETEEGDPKDPPADPEKSTTETPRLALKVPESVHLSIGKDSLTDYLGPPVFTADRLYDTFPPGVTMGLAWTSMGGAALYVESILENALTPESRPGIDITGNLQPVMKESTQIAYSFAKSVLAKQFPENKFFEKAKLHMHCPEGAVPKDGPSAGITMATSLLSLALDHPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGAKKIIFPADNMSDWLELPENIKDGIEGHAVSWYSEVFNILFAELDKDAANKLWQKQLAGKPKKGPLEEDD |
| Enzyme Length | 1108 |
| Uniprot Accession Number | Q4X0Z7 |
| Absorption | |
| Active Site | ACT_SITE 987; /evidence=ECO:0000255|HAMAP-Rule:MF_03120; ACT_SITE 1030; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 605..612; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Features | Active site (2); Chain (1); Compositional bias (5); Domain (2); Nucleotide binding (1); Region (3); Transit peptide (1) |
| Keywords | ATP-binding;DNA-binding;Hydrolase;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Serine protease;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 121,963 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |