| IED ID | IndEnz0002002930 |
| Enzyme Type ID | protease002930 |
| Protein Name |
Lon protease homolog, mitochondrial EC 3.4.21.53 |
| Gene Name | PIM1 DEHA2F21450g |
| Organism | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Debaryomyces Debaryomyces hansenii (Yeast) (Torulaspora hansenii) Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
| Enzyme Sequence | MLRPRTYVRKLAWRCPRKSQLGLRLATSVSSHKSLPLPMNFDISHSQSAFRAYQDIIHRNKSVGDDEPSQRSENENNPSESDKDSNQDPETPKKDKESENDKEPEKEKDIENDNKVSSESNENVTLASSNTGGAAPPNGNNNGDDPDDSNPSLPVDPVTGLYPPLLAIPMKDRPPLPGRPFAINVTDPEVIRSIYTIIDKREPYFVLFHVKDSNEPDTDVINKKDSVYDIGVHCQIIRHTTPRPGVFNVLGYPLERCKLEELTTPSSEKEAKSEEPSKEDAESFPTSYLKGLNVSYATVKPVEDEPYDKSSAEIRSLVESLKTLLSKMGGKNPLEKLQIKEGTDLISDPSKFADFVGSTIHGDPKKIQEILETLNIETRLSRALELLKVELKASLIKESTIHNLSTKADEYQTRLFIKEFIKELQKRAGISESEDKKTSKFDERLKHLKLTEEAMEAYNAEKAKMENQNEHSSELGVSERYLDWLTSIPWGVYSKDHFNIKQAREVLERDHYGLKDVKDRILEFISLGKVSGKVDGKILCLAGPPGTGKTSIAKSIAESLNRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRGGGAASAFLEILDPEQNNSFVDNYIDVKVDLSKVLFVCTANYLGNIPAPLRDRMEIIDVSGYTNNEKIEIAKRHLIPEASKKAGLETNHVSITNETISRLIEKYCRESGLRNVKKLITRIFSKASLKIVEEIEAKEALDSSKEKEGVTASSEEANVNSESTKSNTSQAEPVAESSTDISTKSKVASEKIETKEKKETNKENGQSEEDQQPEPKFVIPEDIKLEITPANLKDYVGPEIYTRDRVYEFPPPGVATGLSYSTSGNGDALYIESILTHSIGSGSGVPGMHVTGSLKDVMKESASIAYSFTKSFMAKNYPDNRFFEAADIHVHCPDGAIPKDGPSAGISFTSSLVSLAINESLPPTVAMTGEITVTGRVLPVGGLREKILGAKRYGCDTIIFPKDIENELEEIPDEVKDGVTFIPVEWYQEVFDKIFPNATAQKCNEVWKEEFAKLDSKKKNKKK |
| Enzyme Length | 1079 |
| Uniprot Accession Number | Q6BKJ4 |
| Absorption | |
| Active Site | ACT_SITE 959; /evidence=ECO:0000255|HAMAP-Rule:MF_03120; ACT_SITE 1002; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 543..550; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Features | Active site (2); Chain (1); Compositional bias (5); Domain (2); Nucleotide binding (1); Region (3); Transit peptide (1) |
| Keywords | ATP-binding;DNA-binding;Hydrolase;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Serine protease;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 119,970 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |