| IED ID | IndEnz0002002965 |
| Enzyme Type ID | protease002965 |
| Protein Name |
Insulin-degrading enzyme-like 2 EC 3.4.24.- Insulysin-like 2 |
| Gene Name | At3g57470 T8H10.70 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MAVGMENATASGECGEILKPRTDKREYRRIVLKNSLEVLLISDPETDKCAASMNVSVGSFTDPEGLEGLAHFLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTSSEDTNYHFDINTDSFYEALDRFAQFFIQPLMSTDATMREIKAVDSEHQNNLLSDSWRMAQLQKHLSREDHPYHKFSTGNMDTLHVRPEENGVDTRSELIKFYDEHYSANIMHLVVYGKENLDKTQGLVEALFQGIRNTNQGIPRFPGQPCTLDHLQVLVKAVPIMQGHELSVSWPVTPSISHYEEAPCRYLGDLIGHEGEGSLFHALKILGWATGLYAGEADWSMEYSFFNVSIDLTDAGHEHMQDILGLLFEYIKVLQQSGVSQWIFDELSAICEAEFHYQAKIDPISYAVDISSNMKIYPTKHWLVGSSLPSKFNPAIVQKVLDELSPNNVRIFWESNKFEGQTDKVEPWYNTAYSLEKITKFTIQEWMQSAPDVNLLLPTPNVFIPTDFSLKDLKDKDIFPVLLRKTSYSRLWYKPDTKFFKPKAYVKMDFNCPLAVSSPDAAVLSDIFVWLLVDYLNEYAYYAQAAGLDYGLSLSDNGFELSLAGFNHKLRILLEAVIQKIAKFEVKPDRFSVIKETVTKAYQNNKFQQPHEQATNYCSLVLQDQIWPWTEELDALSHLEAEDLANFVPMLLSRTFVECYIAGNVEKDEAESMVKHIEDVLFTDSKPICRPLFPSQFLTNRVTELGTGMKHFYYQEGSNSSDENSALVHYIQVHKDEFSMNSKLQLFELIAKQDTFHQLRTIEQLGYITSLSLSNDSGVYGVQFIIQSSVKGPGHIDSRVESLLKDLESKFYNMSDEEFKSNVTNLIDMKLEKDKNLDEESWFYWAEIQTGTLKFNRIDAEVAALRLLKKDEWIDFFDEYIKVDAPNKKSLSICVYGNQHLKEMRNDKDKIPSTSIEIEDIVCFRKSQPLYGSLKL |
| Enzyme Length | 966 |
| Uniprot Accession Number | F4J3D9 |
| Absorption | |
| Active Site | ACT_SITE 74; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; ACT_SITE 145; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous gene model prediction (2); Metal binding (3) |
| Keywords | Alternative splicing;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15937229; 28627464; |
| Motif | |
| Gene Encoded By | |
| Mass | 110,688 |
| Kinetics | |
| Metal Binding | METAL 71; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 75; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 152; /note=Zinc; /evidence=ECO:0000305 |
| Rhea ID | |
| Cross Reference Brenda |