| IED ID | IndEnz0002002975 |
| Enzyme Type ID | protease002975 |
| Protein Name |
Interferon regulatory factor 6 IRF-6 |
| Gene Name | IRF6 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ |
| Enzyme Length | 467 |
| Uniprot Accession Number | O14896 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 7..115; /note=IRF tryptophan pentad repeat; /evidence=ECO:0000255|PROSITE-ProRule:PRU00840 |
| EC Number | |
| Enzyme Function | FUNCTION: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); DNA binding (1); Natural variant (46); Region (1) |
| Keywords | Alternative splicing;Cytoplasm;DNA-binding;Differentiation;Disease variant;Nucleus;Reference proteome;Transcription;Transcription regulation;Ubl conjugation |
| Interact With | Q02556 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11092454; 11337497; 11404376; 12029096; 12964020; 14757865; 14769151; 15013698; 15047845; 1508672; 15647839; 15994871; 16009940; 16132054; 16160700; 16211254; 16998136; 17041603; 1730654; 17318851; 17438386; 17549393; 17551329; 17702008; 17937438; 18209213; 18278815; 18362138; 18452891; 18506368; 18798331; 18813858; 18836445; 18978678; 19115793; 19270707; 19282774; 19372376; 19388848; 19419265; 19449419; 19527266; 19536562; 19536891; 19734457; 19780991; 19842205; 19929101; 19937600; 20032603; 20121942; 20184620; 20424325; 20436469; 20544801; 20564431; 20572854; 20634891; 20652317; 20672350; 20799332; 20848922; 20856073; 21039277; 21129360; 21468557; 21683068; 21792966; 21807998; 21834040; 21885341; 21903422; 21909072; 21995291; 2211721; 22440537; 22487822; 22876587; 22887868; 22931925; 23029012; 23121362; 23154410; 23154523; 23166094; 23169698; 23394314; 23509905; 23510002; 23512105; 23713753; 23921572; 24360809; 24377609; 24442519; 24872416; 25220223; 25246526; 25256005; 25441681; 25489771; 25579819; 25592222; 25784454; 25896037; 25896061; 26086926; 26161746; 26303210; 26346622; 26710774; 26714022; 26819203; 27014863; 27223861; 27286731; 27511269; 27706679; 27834299; 27933721; 28133786; 28289145; 28593555; 28712851; 28767310; 28877249; 28945736; 29017114; 29065370; 29111349; 29211286; 29666346; 30013178; 30053123; 30195270; 30419764; 30462859; 30485383; 30545388; 30593107; 30946036; 31448957; 31495697; 31609978; 31724286; 31901040; 32108996; 32470550; 32527996; 32533457; 32558391; 32784565; 33137956; 33200192; 33334172; 33423258; 33994351; 6162102; 6548414; 7530745; 8176225; 8483949; 8530158; 9096384; 9143706; 9861020; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,130 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |