| IED ID | IndEnz0002002991 |
| Enzyme Type ID | protease002991 |
| Protein Name |
Kininogen Cleaved into: Bradykinin |
| Gene Name | LOC106584303 |
| Organism | Salmo salar (Atlantic salmon) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Euteleosteomorpha Protacanthopterygii Salmoniformes (salmons and trouts) Salmonidae (salmonids) Salmoninae (trouts salmons & chars) Salmo Salmo salar (Atlantic salmon) |
| Enzyme Sequence | MKLGVRLCVLVVFSLQLWGPGQGQELEPEQVLAFCDDKDVEAAVDLALVKYNQKLPYGNQLALYQILESSKAQNDSCTQYFVEFNSRVTDCPAGGDKVWRDCDYLPTGNKVPRPCKATVHMSETDKKVLAVFCDPVEAPVVAERTTCLGCPREIDVESEDLKDPLTYSITRFNADSDSSHHFILNSVGFATRQVVAGFRYRLMFDMRKSNCSKADHKELNDECHPDPDVELAHCNSTVDVAPWRHETAEANVECAPGPLDNFDVFRRRPPGWSPLRNFNNFAEVKTTQASTASAKEESSEESQERSPSAVTMANPEPALPSVAPTTAAESPFHCPSKPWKQFVPPTTLRPAQEKSPTPLPVVEEGLSDLDLLGKK |
| Enzyme Length | 375 |
| Uniprot Accession Number | A0A1S3PBB7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits papain and ficin (cysteine proteinases) but not trypsin (a serine proteinase). {ECO:0000269|PubMed:10583403}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (4); Domain (2); Glycosylation (2); Peptide (1); Signal peptide (1) |
| Keywords | Cleavage on pair of basic residues;Cytoplasm;Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Signal;Thiol protease inhibitor;Vacuole |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12397376}. Vacuole {ECO:0000269|PubMed:12397376}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated, with sialylated biantennary complex-type glycans. {ECO:0000269|PubMed:11447131}.; PTM: O-glycosylated, sialylated oligosaccharides. {ECO:0000269|PubMed:11447131}.; PTM: Bradykinin is released from kininogen by kallikrein. {ECO:0000250|UniProtKB:P01042}.; PTM: The N-terminus is blocked. {ECO:0000269|PubMed:10583403}. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000269|PubMed:10583403 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 41,560 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |