| IED ID | IndEnz0002003000 |
| Enzyme Type ID | protease003000 |
| Protein Name |
Collagen alpha-1 XXV chain Alzheimer disease amyloid-associated protein AMY CLAC-P Cleaved into: Collagen-like Alzheimer amyloid plaque component CLAC |
| Gene Name | COL25A1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK |
| Enzyme Length | 654 |
| Uniprot Accession Number | Q9BXS0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (4); Chain (2); Compositional bias (5); Domain (7); Modified residue (1); Mutagenesis (4); Natural variant (1); Region (5); Sequence conflict (4); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Amyloid;Collagen;Direct protein sequencing;Disease variant;Glycoprotein;Heparin-binding;Hydroxylation;Membrane;Pyrrolidone carboxylic acid;Reference proteome;Repeat;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted. |
| Modified Residue | MOD_RES 113; /note=Pyrrolidone carboxylic acid (Glu); /evidence=ECO:0000269|PubMed:11927537 |
| Post Translational Modification | PTM: Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. {ECO:0000269|PubMed:11927537}.; PTM: Glycosylated. {ECO:0000269|PubMed:15522881}.; PTM: Hydroxylated on 11% of proline residues and 49% of lysine residues. {ECO:0000269|PubMed:11927537, ECO:0000269|PubMed:15522881}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10934207; 12475640; 1323838; 14500733; 15044469; 1577494; 16591531; 171650; 18487197; 18501477; 19075007; 19548013; 19693541; 20332099; 20379614; 20470363; 21688384; 22297151; 23018867; 2543975; 26486031; 3173483; 33287899; 6809411; 710450; 9054364; 9545296; 9560306; 9582318; |
| Motif | |
| Gene Encoded By | |
| Mass | 64,771 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |