| IED ID | IndEnz0002003035 |
| Enzyme Type ID | protease003035 |
| Protein Name |
Epidermin leader peptide-processing serine protease EpiP EC 3.4.21.- |
| Gene Name | epiP |
| Organism | Staphylococcus epidermidis |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus epidermidis |
| Enzyme Sequence | MNKFKFFIVFLILSLVFLQNEYAFGSSLNEELSYYSVEYDNAKTFKESIKQKNIELTYKIPELHTAQIKTSKSKLNSLIKSNKNVKFVNPTCSTCVVEKSVKTGKNLNNKKNGSHDLFDRQWDMRKITNEGKSYKLSPDRKKAKVALVDSGVNSSHTDLKSINKIVNEVPKNGFRGSENDESGNKNFEEDKLNHGTLVAGQIGANGNLKGVNPGVEMNVYRVFGSKKSEMLWVSKGIIDAANDDNDVINVSLGNYLIKDNQNKKKLRDDEKVDYDALQKAINYAQKKGSIVVAAVGNDGINVKKVKEINKKRNLNSKTSKKVYDSPANLNNVMTVGSIDDNDYISEFSNYGNNFIDLMTIGGSYKLLDKYGKDAWLEKGYMQKQSVLSTSSNGRYIYQSGTSLAAPKVSGALALEIDKYQLKDQPETAIELFKKKGIEKEKYMDKKHYGNGKLDVYKLLKE |
| Enzyme Length | 461 |
| Uniprot Accession Number | P30199 |
| Absorption | |
| Active Site | ACT_SITE 149; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 194; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 402; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Protease which cleaves the matured lantibiotic from the modified prepeptide. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Antibiotic biosynthesis; epidermin biosynthesis. |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (1); Propeptide (1); Signal peptide (1) |
| Keywords | Hydrolase;Plasmid;Protease;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | Plasmid pTu 32 |
| Mass | 51,814 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |