Detail Information for IndEnz0002003041
IED ID IndEnz0002003041
Enzyme Type ID protease003041
Protein Name Fibrinogen beta chain
Cleaved into: Fibrinopeptide B
Fragment
Gene Name FGB
Organism Antilocapra americana (Pronghorn)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Antilocapridae Antilocapra Antilocapra americana (Pronghorn)
Enzyme Sequence QPSYDYDEEEDDRAKLRLDAR
Enzyme Length 21
Uniprot Accession Number P14465
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Modified residue (2); Non-terminal residue (1); Peptide (1); Region (1)
Keywords Adaptive immunity;Blood coagulation;Coiled coil;Direct protein sequencing;Disulfide bond;Hemostasis;Immunity;Innate immunity;Pyrrolidone carboxylic acid;Secreted;Sulfation
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|Ref.1; MOD_RES 6; /note=Sulfotyrosine; /evidence=ECO:0000269|Ref.1
Post Translational Modification PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 2,585
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda