| IED ID | IndEnz0002003147 |
| Enzyme Type ID | protease003147 |
| Protein Name |
Glia-derived nexin GDN Peptidase inhibitor 7 PI-7 Protease nexin 1 PN-1 Protease nexin I Serpin E2 |
| Gene Name | SERPINE2 PI7 PN1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP |
| Enzyme Length | 398 |
| Uniprot Accession Number | P07093 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (18); Chain (1); Glycosylation (2); Helix (15); Natural variant (2); Sequence conflict (2); Signal peptide (1); Site (1); Turn (6) |
| Keywords | 3D-structure;Alternative splicing;Developmental protein;Differentiation;Direct protein sequencing;Glycoprotein;Heparin-binding;Neurogenesis;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | Q8IZU0 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:3997857" |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 4DY0; 4DY7; |
| Mapped Pubmed ID | 10781579; 11925594; 12356769; 12859287; 14982929; 16015279; 16085935; 16358219; 16741952; 16921128; 17379830; 17446335; 17690329; 17703087; 17934860; 18550614; 18617644; 19017876; 19111454; 19249338; 19439404; 19584287; 19604412; 19626039; 19789190; 19855083; 19949669; 20035713; 2019570; 20233420; 20298363; 20463177; 20525719; 20623540; 20805453; 20819545; 20942929; 21067581; 21403095; 21426587; 21436250; 21611750; 21806836; 22028159; 22145704; 22331468; 22618708; 23041623; 23385179; 23661674; 24023701; 24587150; 2502206; 2503541; 2505252; 25199049; 25416956; 2544876; 25517131; 25901736; 26214473; 26305372; 26318431; 27193053; 27221371; 27460424; 27793045; 28255192; 2866798; 28677735; 28706437; 28925403; 29084210; 30591111; 3082357; 30923232; 31199037; 31215134; 3134349; 31501409; 31730904; 32495984; 33317533; 33760135; 34173120; 34289555; 34369625; 34648881; 8338946; 9888880; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,002 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |