| IED ID | IndEnz0002003153 |
| Enzyme Type ID | protease003153 |
| Protein Name |
Hypodermin-A HA EC 3.4.21.- |
| Gene Name | |
| Organism | Hypoderma lineatum (Early cattle grub) (Common cattle grub) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Calyptratae Oestroidea Oestridae (warble flies) Hypodermatinae Hypoderma Hypoderma lineatum (Early cattle grub) (Common cattle grub) |
| Enzyme Sequence | MLKFVILLCSIAYVFGAVVPLGMLSQSDGRIVGGVESKIEDFPWQISLQRDGRHYCGGSIYSKNVIITAAHCLRNVVAEELRVRVGSSYWEHGGSLRNISKFQIHESYVEPTKEYDVALLKLDSDLSFNSTIKAIELTNEIPPEYADAIVSGWGETLVPPPGIPDQLRSVDVKIIHREKCASRNFGYGSNIKASMICAYAIGKDSCQGDSGGPLVVNNLLVGVVSWGIDCARPSYPGVYVDVSHVRSLIVSNAESI |
| Enzyme Length | 256 |
| Uniprot Accession Number | P35587 |
| Absorption | |
| Active Site | ACT_SITE 71; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 116; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 210; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Specificity, limited to carboxyl side of arginine residue in B-chain of insulin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (1); Propeptide (1); Sequence conflict (4); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 27,907 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |