| IED ID | IndEnz0002003180 |
| Enzyme Type ID | protease003180 |
| Protein Name |
Ecto-NOX disulfide-thiol exchanger 1 Candidate growth-related and time keeping constitutive hydroquinone NADH oxidase cCNOX Cell proliferation-inducing gene 38 protein Constitutive Ecto-NOX cNOX Includes: Hydroquinone NADH oxidase EC 1.-.-.- ; Protein disulfide-thiol oxidoreductase EC 1.-.-.- |
| Gene Name | ENOX1 PIG38 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT |
| Enzyme Length | 643 |
| Uniprot Accession Number | Q8TC92 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. {ECO:0000269|PubMed:11360993, ECO:0000269|PubMed:12565167}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 1.-.-.-; 1.-.-.- |
| Enzyme Function | FUNCTION: Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:11360993, ECO:0000269|PubMed:12565167, ECO:0000269|PubMed:17027975, ECO:0000269|PubMed:19055324}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Chain (1); Coiled coil (2); Domain (1); Natural variant (1); Sequence conflict (3) |
| Keywords | Alternative splicing;Biological rhythms;Cell membrane;Coiled coil;Copper;Electron transport;Membrane;NAD;Oxidoreductase;Reference proteome;Secreted;Transport |
| Interact With | Q16206-2; Q9H8Y8; Q8TBB1; O00560; Q96BQ3; Q96E35 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11360993}. Secreted, extracellular space {ECO:0000269|PubMed:11360993}. Note=Extracellular and plasma membrane-associated. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16169070; 16189514; 20379614; 22744667; 23939472; 25416956; 26496610; |
| Motif | |
| Gene Encoded By | |
| Mass | 73,348 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |