| IED ID |
IndEnz0002003201 |
| Enzyme Type ID |
protease003201 |
| Protein Name |
Gram-negative bacteria-binding protein 1
|
| Gene Name |
GNBP1 CG6895 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MPGLCIGILLLIGFGCTTAYKIPTPTVELLETGFSVSIPDEEGVKVVAFNVNRNRNFTSFINEGQYNVRLTEPQNGRWTTNFSSVPLRSQDVLYLWTSVQHQKAVYQDLAQPLPVCNLGGEYRPRGCSPGDDDFTDDNQLSTEDSALEPTAPSVCEPSESQVSPQIGVSICKGQLLFEETFDQLNESLWIHDVRLPLDSKDAEFVLYDGKAKVHDGNLVIEPLLWSSYRPDLSIANSRLDLSERCTGTHNRIKECILHSTGSGPSGIMPPIVTPRISTKETFAFQYGRIEIRAKLPKGDWIVPLLLLEPLTEWYGQSGYESGQLRVALARGNSVLRMPRGKLVDGRSLYGGPVLSTDAHQREDLWLSKRKISHFGDDFHTYSLDWSSNRLLFSVDGQVYGEMLNGFTELDENPRWKQGGPMAPFDKMFYISLGVSVGGFGDFVDHLRTATYEKPWANYHPQAKLQFHQAQDQWLPTWKQPALKIDYVRVFATDN |
| Enzyme Length |
494 |
| Uniprot Accession Number |
Q9NHB0 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria (PubMed:10827089). Upon recognition of invading microorganism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin (PubMed:10827089, PubMed:16399077). {ECO:0000269|PubMed:10827089, ECO:0000269|PubMed:16399077}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Domain (2); Frameshift (1); Glycosylation (3); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords |
Cell membrane;GPI-anchor;Glycoprotein;Immunity;Innate immunity;Lipoprotein;Membrane;Reference proteome;Signal |
| Interact With |
Q9VYX7; Q9VS97 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10827089}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10827089}. Note=Secreted and attached to the membrane by a GPI-anchor. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11283698;
11562344;
14603309;
14684822;
14722090;
14734104;
15199954;
15448690;
15791270;
15797611;
16385003;
16497588;
16631589;
16906161;
16941005;
17024181;
17103056;
17190605;
17356067;
17409189;
17588928;
18697931;
18724373;
18823557;
19520911;
19590012;
19851448;
20066029;
20089584;
20551040;
21074052;
21078848;
21390224;
21576362;
21775770;
22144903;
22368770;
22383881;
22410636;
22724070;
22824741;
23071443;
23228366;
23401590;
23632253;
23764256;
23796791;
23868318;
23944235;
24120681;
24127584;
24500162;
25312911;
25421701;
25628309;
27172210;
27851910;
29211760;
29321302;
29670218;
30865231;
31018123;
31430488;
31794428;
32188787;
32656090;
32774336;
32866212;
34705495;
|
| Motif |
|
| Gene Encoded By |
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| Mass |
55,531 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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