IED Industry Enzyme Database

Detail Information for IndEnz0002003206
IED ID IndEnz0002003206
Enzyme Type ID protease003206
Protein Name Hemoglobin subunit alpha
Alpha-globin
Hemoglobin alpha chain
Gene Name HBA1; HBA2
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR
Enzyme Length 142
Uniprot Accession Number P69905
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (2); Chain (1); Erroneous initiation (1); Glycosylation (4); Helix (9); Initiator methionine (1); Metal binding (2); Modified residue (17); Natural variant (151); Sequence conflict (1); Site (19); Turn (4)
Keywords 3D-structure;Acetylation;Direct protein sequencing;Disease variant;Glycation;Glycoprotein;Heme;Hereditary hemolytic anemia;Iron;Metal-binding;Oxygen transport;Phosphoprotein;Reference proteome;Transport
Interact With Q9NZD4; Q2TAC2; P00387; P68871; P02042; P02100; P69892; P09105; Q15323; O76011; Q6A162; P29474; P0DPK4; P0DMV9
Induction
Subcellular Location
Modified Residue MOD_RES 4; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 8; /note=N6-succinyllysine; alternate; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 9; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 12; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 17; /note=N6-acetyllysine; alternate; /evidence=ECO:0007744|PubMed:19608861; MOD_RES 17; /note=N6-succinyllysine; alternate; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 25; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 36; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 41; /note=N6-succinyllysine; alternate; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 50; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 103; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 109; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 125; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 132; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 135; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 138; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 139; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942
Post Translational Modification PTM: The initiator Met is not cleaved in variant Thionville and is acetylated.
Signal Peptide
Structure 3D Neutron diffraction (2); NMR spectroscopy (2); Electron microscopy (3); X-ray crystallography (290)
Cross Reference PDB 1A00; 1A01; 1A0U; 1A0Z; 1A3N; 1A3O; 1A9W; 1ABW; 1ABY; 1AJ9; 1B86; 1BAB; 1BBB; 1BIJ; 1BUW; 1BZ0; 1BZ1; 1BZZ; 1C7B; 1C7C; 1C7D; 1CLS; 1CMY; 1COH; 1DKE; 1DXT; 1DXU; 1DXV; 1FDH; 1FN3; 1G9V; 1GBU; 1GBV; 1GLI; 1GZX; 1HAB; 1HAC; 1HBA; 1HBB; 1HBS; 1HCO; 1HDB; 1HGA; 1HGB; 1HGC; 1HHO; 1IRD; 1J3Y; 1J3Z; 1J40; 1J41; 1J7S; 1J7W; 1J7Y; 1JY7; 1K0Y; 1K1K; 1KD2; 1LFL; 1LFQ; 1LFT; 1LFV; 1LFY; 1LFZ; 1LJW; 1M9P; 1MKO; 1NEJ; 1NIH; 1NQP; 1O1I; 1O1J; 1O1K; 1O1L; 1O1M; 1O1N; 1O1O; 1O1P; 1QI8; 1QSH; 1QSI; 1QXD; 1QXE; 1R1X; 1R1Y; 1RPS; 1RQ3; 1RQ4; 1RQA; 1RVW; 1SDK; 1SDL; 1SHR; 1SI4; 1THB; 1UIW; 1VWT; 1XXT; 1XY0; 1XYE; 1XZ2; 1XZ4; 1XZ5; 1XZ7; 1XZU; 1XZV; 1Y01; 1Y09; 1Y0A; 1Y0C; 1Y0D; 1Y0T; 1Y0W; 1Y22; 1Y2Z; 1Y31; 1Y35; 1Y45; 1Y46; 1Y4B; 1Y4F; 1Y4G; 1Y4P; 1Y4Q; 1Y4R; 1Y4V; 1Y5F; 1Y5J; 1Y5K; 1Y7C; 1Y7D; 1Y7G; 1Y7Z; 1Y83; 1Y85; 1Y8W; 1YDZ; 1YE0; 1YE1; 1YE2; 1YEN; 1YEO; 1YEQ; 1YEU; 1YEV; 1YFF; 1YG5; 1YGD; 1YGF; 1YH9; 1YHE; 1YHR; 1YIE; 1YIH; 1YVQ; 1YVT; 1YZI; 1Z8U; 2D5Z; 2D60; 2DN1; 2DN2; 2DN3; 2DXM; 2H35; 2HBC; 2HBD; 2HBE; 2HBF; 2HBS; 2HCO; 2HHB; 2HHD; 2HHE; 2M6Z; 2W6V; 2W72; 2YRS; 3B75; 3D17; 3D7O; 3DUT; 3HHB; 3HXN; 3IA3; 3IC0; 3IC2; 3KMF; 3NL7; 3NMM; 3ODQ; 3ONZ; 3OO4; 3OO5; 3OVU; 3P5Q; 3QJB; 3QJC; 3QJD; 3QJE; 3R5I; 3S48; 3S65; 3S66; 3SZK; 3WCP; 3WHM; 4FC3; 4HHB; 4IJ2; 4L7Y; 4M4A; 4M4B; 4MQC; 4MQG; 4MQH; 4MQI; 4MQJ; 4MQK; 4N7N; 4N7O; 4N7P; 4N8T; 4NI0; 4NI1; 4ROL; 4ROM; 4WJG; 4X0L; 4XS0; 5E29; 5E6E; 5E83; 5EE4; 5HU6; 5HY8; 5JDO; 5KDQ; 5KSI; 5KSJ; 5NI1; 5SW7; 5U3I; 5UCU; 5UFJ; 5URC; 5VMM; 5WOG; 5WOH; 5X2R; 5X2S; 5X2T; 5X2U; 6BB5; 6BNR; 6BWP; 6BWU; 6DI4; 6HAL; 6HBW; 6HK2; 6KA9; 6KAE; 6KAH; 6KAI; 6KAO; 6KAP; 6KAQ; 6KAR; 6KAS; 6KAT; 6KAU; 6KAV; 6KYE; 6L5V; 6L5W; 6L5X; 6L5Y; 6LCW; 6LCX; 6NBC; 6NBD; 6NQ5; 6TB2; 6XD9; 6XDT; 6XE7; 7AET; 7AEU; 7AEV; 7CUE; 7JJQ; 7JXZ; 7JY0; 7JY1; 7JY3; 7K4M;
Mapped Pubmed ID 10390349; 10512707; 10529219; 10611283; 10698631; 10794410; 10930827; 10930828; 11159543; 11196644; 11304851; 11316875; 11724557; 11833853; 11877072; 11914488; 11939517; 12054662; 12072504; 12077435; 12200073; 12454461; 12454462; 1252417; 12525687; 12659864; 12667291; 12673836; 12773618; 13342742; 13472068; 1390648; 1395; 14508795; 1453464; 14649314; 14705937; 14958; 15008263; 15131110; 15174051; 15236579; 15341482; 15365991; 15448162; 15449937; 1552945; 15550245; 1567857; 15751957; 15768555; 15824313; 15835899; 15858218; 15858266; 15882059; 15921165; 15931225; 15938624; 15941417; 16042697; 16046400; 16123516; 16169070; 16189277; 16302974; 16370488; 16403522; 16466950; 16540409; 16545695; 16760505; 16765986; 16778136; 16822864; 16898315; 16933182; 16992238; 16994616; 17008602; 17040989; 17060917; 17070510; 17102136; 17112520; 17132905; 17191128; 17351274; 17353931; 17355907; 17394396; 17626702; 17691822; 17724704; 17845074; 17916326; 17938644; 17990881; 18026953; 18166800; 18211634; 18215251; 18343267; 18458302; 18485513; 18571503; 18582194; 18591626; 18609043; 18630930; 18654888; 18667812; 18689979; 18694998; 18768527; 18772456; 18809301; 18932070; 18932071; 1896430; 19048483; 19096518; 19119852; 19135755; 19168253; 19205971; 19215610; 19245215; 19288145; 19324878; 19341324; 19359777; 19365817; 19371220; 19390853; 19404566; 19479992; 19482015; 19492149; 19533865; 19535894; 19614793; 19651813; 19657833; 19667949; 19706593; 19766903; 19774216; 19794088; 19843387; 19878106; 19912309; 19929282; 19958194; 19958200; 19968714; 20036801; 20054848; 20080971; 20103712; 20144437; 20162361; 20171600; 20190015; 20215002; 20230836; 20308881; 20398260; 20430887; 20517157; 20580289; 20598923; 20639625; 20642333; 20674309; 20682466; 20691621; 20709501; 20711500; 20832374; 20836851; 20854119; 20923991; 21041929; 21062041; 21075281; 21077767; 21093326; 21093939; 21111636; 21123872; 21139250; 21193395; 21453942; 21468611; 21474403; 21565611; 21570686; 21623344; 21636902; 21663496; 21697890; 21703224; 21712777; 21717470; 21797699; 21797701; 21821711; 21835487; 21840616; 21863786; 21883672; 21900206; 21917915; 21930529; 21931690; 21967524; 21982282; 21988832; 22038702; 22056776; 22135621; 22138077; 22183073; 22295973; 22304920; 22309488; 22324317; 22374170; 22391447; 22403498; 22406180; 22425018; 22427940; 22433445; 22440250; 22452989; 22456438; 22456695; 22461535; 22531344; 22552911; 22563848; 22623428; 22633797; 22638758; 22658796; 22738435; 22769585; 22805289; 22815750; 22831708; 22870185; 22878698; 22922649; 22924376; 22939970; 22943743; 22985301; 23041240; 23094635; 23114538; 23123858; 23138098; 23168569; 23181747; 23198814; 23270560; 23274140; 23289667; 23312704; 23349856; 23368878; 23390935; 23402770; 23452328; 23485345; 23517369; 23538348; 23555584; 23590659; 23594745; 23614625; 23638175; 23666248; 23672273; 23685023; 23696640; 23705980; 2370669; 23715962; 23757192; 23777413; 23797957; 23799006; 23806041; 2383372; 23865389; 23877985; 23879397; 23896219; 23901897; 23993260; 24018802; 24026558; 24055685; 24055728; 24074341; 24081251; 24100324; 24136020; 24149619; 24168396; 24271460; 24300714; 24351118; 24354578; 24395608; 24425866; 24452365; 24453292; 24471655; 24471736; 24518549; 24530052; 24556928; 24563159; 24578002; 24618476; 24627726; 24635037; 24761863; 24762059; 24769418; 24795058; 24826793; 24857170; 24887924; 24893965; 24979558; 24996234; 25042611; 25061917; 2506737; 25079862; 25084376; 25123009; 25139985; 25158164; 25218786; 25222045; 25231510; 25238043; 25242683; 25247841; 25249479; 25266893; 25284125; 25287606; 25342395; 25410714; 25416956; 25458507; 25476779; 25497229; 25500521; 25569658; 25648458; 25770690; 25834820; 25854289; 25858298; 25874454; 25875773; 25974708; 25976463; 25979978; 26057669; 26125284; 26239161; 26252098; 26261612; 26266799; 26316481; 26329872; 26377141; 26484352; 26496610; 26520892; 26531168; 26582149; 26643952; 26671256; 26683685; 26683994; 26824043; 26824843; 26930363; 26949259; 26995402; 27060306; 27083048; 27085422; 27105433; 27173219; 27206471; 27377386; 27378309; 2738915; 27431507; 27431674; 27529207; 27647169; 28213526; 28224676; 28337324; 28342932; 28345646; 28356267; 28381876; 28395547; 28459140; 28503568; 28665412; 28858508; 28883619; 28898252; 28931607; 29127281; 29246762; 29559230; 29634905; 29655608; 29737888; 30025477; 30183107; 30277083; 30289405; 30289410; 30309760; 30451045; 30595158; 30755556; 30768636; 30833564; 30844732; 31084368; 31145010; 3119859; 31304855; 3136125; 31440863; 31461223; 31467393; 31468979; 31478238; 31509281; 31690131; 31840728; 31899996; 31933393; 32000548; 32019385; 32032239; 32071219; 32338097; 32407278; 32420790; 32436451; 32482156; 32552204; 32605393; 32679799; 32712856; 32727229; 32751969; 32756921; 32831051; 32936915; 33023349; 33034919; 33035409; 33040780; 33049600; 33054440; 33054450; 33059634; 33205981; 33219275; 33222574; 33352376; 33356244; 33639896; 33723266; 33734896; 33960673; 3427020; 34412655; 34543525; 3938604; 4008491; 4203704; 4327491; 4514311; 4647257; 4975618; 5135507; 5656372; 6094553; 6417382; 6644819; 6683087; 6726807; 7263686; 7378053; 7541176; 7723849; 7929044; 8300612; 8377203; 8415693; 8639491; 8639677; 8642597; 8647854; 881729; 8855948; 9032082; 9223274; 9325099; 9441940; 9521756; 9649306; 9761903; 9830011; 9843411; 9876125; 9894000;
Motif
Gene Encoded By
Mass 15,258
Kinetics
Metal Binding METAL 59; /note=Iron (heme distal ligand); METAL 88; /note=Iron (heme proximal ligand)
Rhea ID
Cross Reference Brenda