| IED ID | IndEnz0002003278 |
| Enzyme Type ID | protease003278 |
| Protein Name |
Lon protease homolog 2, peroxisomal EC 3.4.21.53 |
| Gene Name | lonp2 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MASSGSIQIPRRLPLLLTHEGVLLPGSTMRTSVDTPGNMELVQNRLLRGTSLKSTIIGVVPNTSDPSSDREELPSLHRIGTAALAVQVVGSNWPKPHYTLLVTGLCRFQITEILKERPYPVAEVEQLDRLEQLSSKEEFKEALGDLSEQFYKYAVQLVDMLDNSVPAVAKLKRLLNNLPKELLPDVLTSIIRTTNEEKLQILDAVSLEERFKVTIPLLLRQIEGLKLLQKTRNPKQDDDKRIVAIRPPRKLGNISSKSFSLENTDDDDEDSDDIIILERKIKSSNMPEPALKVCVKEIKRLKKMPQSMPEYALTRNYLELMSELPWSKTTRDRLDIRAARILLDNDHYAMAKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSIAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKIVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEVLEVPGYSQEEKLEIAHRHLISKQLAQHGLTPEQIQIPQEATLEIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHREHKSEHLEAPEGEERKESVPEGSKSATINDTADFALPPEMPILIDHHALKDILGPPMYETEVFGRLNQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNASGSFDLLDNTDIHLHFPAGAVTKDGPSAGVAIVTCLASLFSGRLVCSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKRVILPKRNETDLEEIPLNVRQDLEFVLAGSLDEVLNAAFDGGFSLKTTPDLLNSKL |
| Enzyme Length | 856 |
| Uniprot Accession Number | Q2TAF8 |
| Absorption | |
| Active Site | ACT_SITE 747; /evidence=ECO:0000255|HAMAP-Rule:MF_03121; ACT_SITE 790; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03121}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. {ECO:0000255|HAMAP-Rule:MF_03121}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 379..386; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Features | Active site (2); Chain (1); Compositional bias (1); Domain (2); Motif (1); Nucleotide binding (1); Region (1) |
| Keywords | ATP-binding;Hydrolase;Nucleotide-binding;Peroxisome;Protease;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000255|HAMAP-Rule:MF_03121}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 854..856; /note=Microbody targeting signal; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Gene Encoded By | |
| Mass | 94,572 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |