| IED ID | IndEnz0002003279 |
| Enzyme Type ID | protease003279 |
| Protein Name |
Complement component receptor 1-like protein Complement regulatory protein Crry Protein p65 |
| Gene Name | Cr1l Crry Cry |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEVSSRSSEPLDPVWLLVAFGRGGVKLEVLLLFLLPFTLGELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISGLIVGIFIGIIVFILVIIVFIWMILKYKKRNTTDEKYKEVGIHLNYKEDSCVRLQSLLTSQENSSTTSPARNSLTQEVS |
| Enzyme Length | 483 |
| Uniprot Accession Number | Q64735 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. {ECO:0000269|PubMed:10642554, ECO:0000269|PubMed:10779754, ECO:0000269|PubMed:11986227, ECO:0000269|PubMed:1730912, ECO:0000269|PubMed:7528766}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Disulfide bond (10); Domain (5); Frameshift (2); Glycosylation (2); Modified residue (5); Sequence conflict (9); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | 3D-structure;Alternative splicing;Complement pathway;Developmental protein;Disulfide bond;Glycoprotein;Immunity;Innate immunity;Membrane;Phosphoprotein;Pregnancy;Receptor;Reference proteome;Repeat;Signal;Sushi;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | MOD_RES 454; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 460; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"; MOD_RES 463; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:19144319"; MOD_RES 468; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 477; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079" |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..40; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1NTL; |
| Mapped Pubmed ID | 10586048; 11217851; 11698469; 11907125; 11915940; 12393518; 12466851; 12902517; 12914820; 12973023; 14610273; 14670299; 1543915; 16002709; 16127466; 16301324; 16301687; 16444293; 16887189; 17015675; 17015743; 17082645; 17674370; 17916747; 18524992; 18684964; 18799693; 18947875; 19124833; 19136662; 19281793; 19740350; 20484840; 20660348; 20675597; 20941861; 21151910; 21215189; 21267068; 21380996; 2139460; 21677637; 21677750; 22219359; 23109726; 23153828; 23341629; 23382219; 23390291; 24194600; 24632830; 24850152; 25284781; 2528587; 2564419; 27165610; 27626380; 28057640; 28348233; 2952719; 30217731; 7898049; 8138038; 8335915; 8422330; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,763 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |