| IED ID |
IndEnz0002003284 |
| Enzyme Type ID |
protease003284 |
| Protein Name |
Flotillin-1
|
| Gene Name |
FLOT1 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA |
| Enzyme Length |
427 |
| Uniprot Accession Number |
O75955 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (1); Chain (1); Modified residue (4); Natural variant (1); Sequence conflict (3) |
| Keywords |
Alternative splicing;Cell membrane;Endosome;Membrane;Phosphoprotein;Reference proteome |
| Interact With |
P05067; Q8N9N5-2; Q68D86; P10606; P54852; Q86YD7; Q14254; P42858; Q9Y5B8 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000269|PubMed:17081065}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250|UniProtKB:O08917, ECO:0000269|PubMed:17081065}. |
| Modified Residue |
MOD_RES 19; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:24275569"; MOD_RES 163; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 385; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"; MOD_RES 387; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:23186163" |
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10037681;
10212252;
10490598;
10619026;
10873388;
12221077;
14708344;
15469992;
15545008;
15866170;
15939299;
16169070;
16198165;
16341206;
16480949;
16630611;
17113085;
17307333;
17587329;
17600709;
18000879;
18158243;
18218625;
18660489;
18829452;
18850735;
19121286;
19258392;
19318123;
19348413;
19404397;
19738201;
19815536;
19851445;
20027317;
20030946;
20101212;
20360068;
20591975;
20600927;
20660154;
21187433;
21351730;
21399631;
21447726;
21576392;
21674799;
21699497;
21988832;
21994455;
22190034;
22215737;
22232557;
22623428;
22669515;
22790947;
22869152;
22992742;
23012365;
23064789;
23416715;
23581411;
23602568;
23625312;
23627023;
23840303;
24042857;
24046456;
24128008;
24167781;
24277378;
24304721;
24316671;
24330780;
24533441;
24612608;
24695539;
24703947;
24747692;
24809731;
24813885;
24830726;
24886554;
24890092;
24983503;
25180832;
25793370;
25948494;
26413934;
26496610;
26638075;
26646322;
26682635;
27221048;
27346727;
27448302;
28645295;
28825855;
29146911;
30064230;
30452906;
30631151;
30771789;
30820716;
30838797;
30914515;
31105010;
31138766;
31683489;
31871319;
32027876;
33242069;
33846817;
34115333;
34135428;
8543060;
8571126;
8617235;
8662891;
8756646;
8816443;
9013646;
9111050;
9418861;
9535835;
9792683;
9829970;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
47,355 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|