| IED ID | IndEnz0002003295 |
| Enzyme Type ID | protease003295 |
| Protein Name |
Antihemorrhagic factor HSF Habu serum factor Metalloproteinase inhibitor |
| Gene Name | |
| Organism | Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Protobothrops Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis) |
| Enzyme Sequence | MNSLVALVLLGQIIGSTLSSQVRGDLECDDKEAKNWADDAVRYINEHKLHGHKQALNVIKNICVVPWNGDLVAVFLELNLLETECHVLDPTPVEKCTVRQQHNHAVEMDCDAKIMFNVETFKRDVFVKCHSTPDSVENVRRNCSKCPILLPPNNPHVVDSVEYVLNKHNEKLSGHIYEVLEISRGQHKYEPEAYYLEFVIVEINCTAQEAHDDHHQCHPYTAGEDHIAFCRSTVFRSHASLEKPKDEKFESNCVILDVKDGHAHSHLIQQHIEKNSISPEHNITILNFVHPDDHTSTSHESHEHVAEVPVVFVKKELPTDISDHHTTPVKGCPGKVHHFKLY |
| Enzyme Length | 342 |
| Uniprot Accession Number | P29695 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits hemorrhagic and proteolytic activities of metalloproteinases (HR1A, HR1B, HR2a, HR2b and H2 proteinase from T.flavodidis and brevilysins H3, H4, H6 and L4 from A.halys brevicaudus). Has no effect on brevilysins H2. Has no effect on papain and cathepsin-B. {ECO:0000269|PubMed:16289179}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (6); Domain (2); Glycosylation (3); Motif (1); Region (1); Sequence conflict (5); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Glycoprotein;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Repeat;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Cys-63 may exist in a mixed disulfide form with a thiol compound such as glutathione. |
| Signal Peptide | SIGNAL 1..19; /evidence="ECO:0000269|PubMed:1478916, ECO:0000269|PubMed:16289179, ECO:0000269|PubMed:17222882" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 23..25; /note=Cell attachment site |
| Gene Encoded By | |
| Mass | 38,916 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |