| IED ID | IndEnz0002003399 |
| Enzyme Type ID | protease003399 |
| Protein Name |
Leucine aminopeptidase 1 EC 3.4.11.- Leucyl aminopeptidase 1 LAP1 |
| Gene Name | LAP1 HCDG_05552 |
| Organism | Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Histoplasma Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Enzyme Sequence | MKFPNLLSLGVAASTTVLAAVPNQKPIGDTIEDVHLGKFLIELGPGDTRWVTEEEKWGLRRDGRRFFDITAEAEQNVFPRTFAQTTVTFPTELQNLAHVKKLASSLSKNRLQTFLTKFTSFYTRYYKSESGRQSAIWLFEQIEKTIQESSATEARVEKFEHPWGQFSIIATIPGQTNKTVVVGAHQDSINLLMPSILAAPGADDDGSGTATILEALRVLLKSEAVAQGKAPNTVEFHWYSAEEAGLLGSQAVFAQYKQDNRDVKSMLQQDMTGYSKGTMNAGHADSVGIITDFVDEGLTNFIKKVVTGYCGISYVLTKCGYACSDHASASRYGYPSAFVIESKFEYSSKLIHTTRDEVSSLDFDHMLQHAKMTLGLVYELAFADL |
| Enzyme Length | 385 |
| Uniprot Accession Number | C6HH71 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.11.- |
| Enzyme Function | FUNCTION: Extracellular aminopeptidase that allows assimilation of proteinaceous substrates. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Glycosylation (1); Metal binding (6); Propeptide (1); Signal peptide (1) |
| Keywords | Aminopeptidase;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,590 |
| Kinetics | |
| Metal Binding | METAL 185; /note=Zinc 1; /evidence=ECO:0000250; METAL 204; /note=Zinc 1; /evidence=ECO:0000250; METAL 204; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 243; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 270; /note=Zinc 1; /evidence=ECO:0000250; METAL 352; /note=Zinc 2; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |