| IED ID | IndEnz0002003466 |
| Enzyme Type ID | protease003466 |
| Protein Name |
CAAX prenyl protease 1 homolog EC 3.4.24.84 Farnesylated proteins-converting enzyme 1 AtFACE-1 FACE-1 Prenyl protein-specific endoprotease 1 Zinc metalloproteinase Ste24 homolog AtSTE24 |
| Gene Name | FACE1 STE24 At4g01320 A_IG002N01.21 F2N1.21 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MAIPFMETVVGFMIVMYIFETYLDLRQLTALKLPTLPKTLVGVISQEKFEKSRAYSLDKSYFHFVHEFVTILMDSAILFFGILPWFWKMSGAVLPRLGLDPENEILHTLSFLAGVMTWSQITDLPFSLYSTFVIESRHGFNKQTIWMFIRDMIKGTFLSVILGPPIVAAIIFIVQKGGPYLAIYLWAFMFILSLVMMTIYPVLIAPLFNKFTPLPDGDLREKIEKLASSLKFPLKKLFVVDGSTRSSHSNAYMYGFFKNKRIVLYDTLIQQCKNEDEIVAVIAHELGHWKLNHTTYSFIAVQILAFLQFGGYTLVRNSTDLFRSFGFDTQPVLIGLIIFQHTVIPLQHLVSFGLNLVSRAFEFQADAFAVKLGYAKDLRPALVKLQEENLSAMNTDPLYSAYHYSHPPLVERLRAIDGEDKKTD |
| Enzyme Length | 424 |
| Uniprot Accession Number | Q8RX88 |
| Absorption | |
| Active Site | ACT_SITE 285; /evidence=ECO:0000250; ACT_SITE 366; /note=Proton donor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.; EC=3.4.24.84; |
| DNA Binding | |
| EC Number | 3.4.24.84 |
| Enzyme Function | FUNCTION: Proteolytically removes the C-terminal three residues of farnesylated proteins. The substrate specificity is only partially overlapping with that of FACE2. {ECO:0000269|PubMed:12039957}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous gene model prediction (2); Metal binding (3); Mutagenesis (1); Sequence conflict (3); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12039957, ECO:0000269|PubMed:18641086}; Multi-pass membrane protein {ECO:0000269|PubMed:12039957, ECO:0000269|PubMed:18641086}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12185496; 15215502; 16618929; 18441225; 18650403; 18775970; 18957507; 23940253; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,482 |
| Kinetics | |
| Metal Binding | METAL 284; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 288; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 362; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.84; |