| IED ID | IndEnz0002003471 |
| Enzyme Type ID | protease003471 |
| Protein Name |
CAAX prenyl protease 1 homolog EC 3.4.24.84 Zinc metalloproteinase Ste24 homolog |
| Gene Name | TsSte24p |
| Organism | Taenia solium (Pork tapeworm) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Cestoda Eucestoda Cyclophyllidea Taeniidae Taenia Taenia solium (Pork tapeworm) |
| Enzyme Sequence | MDVGGALDLYGCSVNVYNAILIFIWVLFLWETYINLRQLKVAKRVTESPEEIKCLMNDVDFDKSRRYAIDKMNFDIVSGFYNILSLSAVLYFQLIAWAWHKSQEHMLFVCSYAPRSFGTTEGSEILFSLLFTVYVALFQFFESLPWSYYRHFVIEERYGFNKQTIGFFIKDRLKSLAVGLVIGLPIISMLVWIIKAGGHYFYIYAYGFTFVVSFIIMFIYPEFIAPIFDRYEHFPDCELRKKIEELAASIEFPLKKLYVVEGSKRSSHSNAYFYGFGKNKRIVLFDTLIKGFKMPGVEADSSANADESSDETQNRGCGDDEEILATLAHELGHWKLKHMTFNLIIAQINIFFMFFAFGQLINVDQLFVDFGFPPSTAPILIRLIVVFQFIFMPYSSVLEFLMTMLSRKFEFQADAFAVSLKSGEKLKSALLVLTKDNLSFPVYDWLYSMCNHSHPPIIERLAAIDAKMGKEK |
| Enzyme Length | 472 |
| Uniprot Accession Number | Q3Y6B8 |
| Absorption | |
| Active Site | ACT_SITE 330; /evidence=ECO:0000250|UniProtKB:O75844; ACT_SITE 414; /note=Proton donor; /evidence=ECO:0000255 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by ethylenediaminetetraacetic acid (EDTA) but not by serine, aspartic or cysteine protease inhibitors. Inhibited by high concentration of Zn(2+) (> 0.1 mM). {ECO:0000269|PubMed:16750535}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.; EC=3.4.24.84; Evidence={ECO:0000250|UniProtKB:Q9XVE5}; |
| DNA Binding | |
| EC Number | 3.4.24.84 |
| Enzyme Function | FUNCTION: Zinc-dependent metalloproteinase (PubMed:16750535). Proteolytically removes the C-terminal three residues of farnesylated proteins (By similarity). {ECO:0000250|UniProtKB:Q9XVE5, ECO:0000269|PubMed:16750535}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 37 degrees Celsius. Loss of catalytic activity at temperatures above 50 degrees Celsius. {ECO:0000269|PubMed:16750535}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:16750535}; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Metal binding (3); Topological domain (8); Transmembrane (7) |
| Keywords | Disulfide bond;Endoplasmic reticulum;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P47154}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 54,546 |
| Kinetics | |
| Metal Binding | METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:O75844; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:O75844; METAL 410; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:O75844 |
| Rhea ID | |
| Cross Reference Brenda |