| IED ID | IndEnz0002003480 |
| Enzyme Type ID | protease003480 |
| Protein Name |
COP9 signalosome complex subunit 6 Dch6 Signalosome subunit 6 |
| Gene Name | CSN6 CG6932 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MEQMEVDVDMSAKPSTSSSAAAGSSMAVDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWTRFRAQHGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWYTTGDNPTADDIKIQRQIAAINECPIMLQLNPLSRSVDHLPLKLFESLIDLVDGEATMLFVPLTYTLATEEAERIGVDHVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQEILREAYALCHRLPVMQVPAFQEEFYTQCNDVGLISYLGTLTKGCNDMHHFVNKFNMLYDRQGSARRMRGLYY |
| Enzyme Length | 341 |
| Uniprot Accession Number | Q9VCY3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. {ECO:0000269|PubMed:12737805}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (7); Chain (1); Compositional bias (1); Domain (1); Helix (4); Region (1) |
| Keywords | 3D-structure;Cytoplasm;Developmental protein;Differentiation;Nucleus;Oogenesis;Reference proteome;Signalosome |
| Interact With | Q9V345; Q9XZ58; Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:10531038}. Nucleus {ECO:0000305|PubMed:10531038}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4E0Q; |
| Mapped Pubmed ID | 10782111; 12850443; 14570571; 14605208; 15735686; 16496002; 17251548; 17486136; 19363474; 20068067; 20220848; 20371351; 20585616; 21074052; 21205937; 21548953; 22036573; 22575649; 22935612; 22937016; 23071443; 23173097; 23275879; 23583758; 23899565; 24576427; 25119050; 25312911; 25393278; 25459658; 26526100; 26551273; 26672093; 26870755; 26912791; 27172210; 28619822; 31722958; 33561251; 33988679; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,306 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |