| IED ID | IndEnz0002003501 |
| Enzyme Type ID | protease003501 |
| Protein Name |
Hepatocyte growth factor activator HGF activator HGFA EC 3.4.21.- Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain |
| Gene Name | HGFAC |
| Organism | Canis lupus familiaris (Dog) (Canis familiaris) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris) |
| Enzyme Sequence | MGRWAWGPSLCPLPGMALLLLLLLLLVPHGAQPQAGGNLTEPPEPNATVTPGTPMIPVTSVTPVTPATSAPEAQGPRGRGLTPPPRAAPSSSSPGDPVLTVDGQPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVQAPVSREGPAALDSCASSPCLNGGSCSHTQDPGSYHCTCPMAFTGRNCDTEKCFDETRYEHLEAGDRWARVSQGQVEQCECAGGQIRCEGTRHTACLSSPCLNGGTCHLIVATGTTVCSCPPGHAGRLCNIVPSQRCFVGNGTEYRGVASTAASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDKDERPWCYVVKDSALSWEYCRLAACESLARIPSLTTAVLLSQAEPAPVGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSNSPRRESVLVVLGQHFFNQTTDVTQTFGIEKYIPYPMYSVFNPSDHDLVLIRLKKKGDRCAIRSQFVQPICLPEPSSPFPAGHKCQIAGWGHQDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLNKPGVYTRVAKYVDWIKDRIWPSKRPSDPS |
| Enzyme Length | 654 |
| Uniprot Accession Number | Q6QNF4 |
| Absorption | |
| Active Site | ACT_SITE 446; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 496; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 597; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (2); Compositional bias (1); Disulfide bond (19); Domain (6); Glycosylation (5); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Kringle;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 70,245 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |