| IED ID | IndEnz0002003546 |
| Enzyme Type ID | protease003546 |
| Protein Name |
Integrin alpha-X CD11 antigen-like family member C Leu M5 Leukocyte adhesion glycoprotein p150,95 alpha chain Leukocyte adhesion receptor p150,95 CD antigen CD11c |
| Gene Name | ITGAX CD11C |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK |
| Enzyme Length | 1163 |
| Uniprot Accession Number | P20702 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 466..474; CA_BIND 530..538; CA_BIND 593..601 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (81); Calcium binding (3); Chain (1); Disulfide bond (10); Domain (1); Glycosylation (8); Helix (21); Metal binding (16); Motif (1); Natural variant (8); Repeat (7); Sequence conflict (15); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (18) |
| Keywords | 3D-structure;Calcium;Cell adhesion;Direct protein sequencing;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | P05107 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000269|PubMed:3549901 |
| Structure 3D | NMR spectroscopy (1); X-ray crystallography (7) |
| Cross Reference PDB | 1N3Y; 2LUV; 3K6S; 3K71; 3K72; 4NEH; 4NEN; 5ES4; |
| Mapped Pubmed ID | 10543983; 11937543; 12083416; 12100475; 12208882; 12351396; 12554829; 12576324; 14715956; 15665082; 15730520; 15900581; 16037628; 16716806; 17045822; 17339034; 17525755; 17625065; 17726152; 17726260; 18047418; 18204098; 18386786; 18541300; 18580071; 19129174; 19237023; 19257981; 19800635; 19910635; 20032971; 20382884; 20574620; 20610651; 20660331; 20679211; 20711500; 20888334; 20962850; 21030716; 21239711; 21257965; 21273385; 21362770; 21666055; 21874872; 22244783; 22393018; 22539788; 22844116; 23118428; 23246582; 23650620; 24124148; 24129562; 24385486; 25155097; 25231265; 25278023; 25361058; 26153037; 26255872; 26306739; 26309367; 26852488; 26927560; 26936951; 26968188; 27108704; 27119555; 27309860; 28535664; 28603911; 28756897; 28838763; 30348717; 30873824; 31227791; 32824307; 33032823; 33133077; 33372665; 33539617; 34283878; 7529288; 7559467; 7693733; 7907877; 8798654; 9723655; 9949188; |
| Motif | MOTIF 1131..1135; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 127,829 |
| Kinetics | |
| Metal Binding | METAL 157; /note=Magnesium; METAL 159; /note=Magnesium; METAL 161; /note=Magnesium; METAL 259; /note=Magnesium; METAL 466; /note=Calcium 2; METAL 468; /note=Calcium 2; METAL 470; /note=Calcium 2; METAL 472; /note=Calcium 2; via carbonyl oxygen; METAL 532; /note=Calcium 3; METAL 534; /note=Calcium 3; METAL 536; /note=Calcium 3; via carbonyl oxygen; METAL 593; /note=Calcium 1; METAL 595; /note=Calcium 1; METAL 597; /note=Calcium 1; METAL 599; /note=Calcium 1; via carbonyl oxygen; METAL 601; /note=Calcium 1 |
| Rhea ID | |
| Cross Reference Brenda |