| IED ID | IndEnz0002003554 |
| Enzyme Type ID | protease003554 |
| Protein Name |
Protein DA1-related 2 Protein LATERAL ROOT DEVELOPMENT 3 |
| Gene Name | DAR2 LRD3 At2g39830 T5I7.13 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MDSSSSSSSSSPSSSYGVARVSHISNPCIFGEVGSSSSSTYRDKKWKLMKWVSKLFKSGSNGGGSGAHTNHHPPQFQEDENMVFPLPPSSLDDRSRGARDKEELDRSISLSLADNTKRPHGYGWSMDNNRDFPRPFHGGLNPSSFIPPYEPSYQYRRRQRICGGCNSDIGSGNYLGCMGTFFHPECFRCHSCGYAITEHEFSLSGTKPYHKLCFKELTHPKCEVCHHFIPTNDAGLIEYRCHPFWNQKYCPSHEYDKTARCCSCERLESWDVRYYTLEDGRSLCLECMETAITDTGECQPLYHAIRDYYEGMYMKLDQQIPMLLVQREALNDAIVGEKNGYHHMPETRGLCLSEEQTVTSVLRRPRLGAHRLVGMRTQPQRLTRKCEVTAILVLYGLPRLLTGAILAHELMHGWLRLNGFRNLNPEVEEGICQVLSYMWLESEVLSDPSTRNLPSTSSVATSSSSSFSNKKGGKSNVEKKLGEFFKHQIAHDASPAYGGGFRAANAAACKYGLRRTLDHIRLTGTFPL |
| Enzyme Length | 528 |
| Uniprot Accession Number | Q0WSN2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Acts redundantly with DA1 and DAR1 to regulate endoreduplication during leaf development. Together with DA1 and DAR1, modulates the protein stability of the transcription factors TCP14 and TCP15, which repress endoreduplication by directly regulating the expression of cell-cycle genes (PubMed:25757472). Involved in root phloem development. Is an essential component of early phloem development, long-distance delivery of phloem content, and proper maintenance of root system architecture (PubMed:21749503). Involved in the control of root meristem size. Functions genetically downstream of cytokinin and IAA3 to maintain normal auxin distribution by influencing polar auxin transport. Acts through the PLETHORA pathway, upstream of PLT1 and PLT2 to influence root stem cell niche activity and thus control root meristem size (PubMed:23296689). {ECO:0000269|PubMed:21749503, ECO:0000269|PubMed:23296689, ECO:0000269|PubMed:25757472}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Domain (3); Erroneous gene model prediction (1); Region (2) |
| Keywords | LIM domain;Metal-binding;Reference proteome;Repeat;Ubl conjugation;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: Polyubiquitinated by DA2. {ECO:0000269|PubMed:28167503}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12481096; 14576160; 23518585; |
| Motif | |
| Gene Encoded By | |
| Mass | 59,426 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |