| IED ID | IndEnz0002003577 |
| Enzyme Type ID | protease003577 |
| Protein Name |
Insulin Cleaved into: Insulin B chain; Insulin A chain |
| Gene Name | INS |
| Organism | Sus scrofa (Pig) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Suina Suidae (pigs) Sus Sus scrofa (Pig) |
| Enzyme Sequence | MALWTRLLPLLALLALWAPAPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREAENPQAGAVELGGGLGGLQALALEGPPQKRGIVEQCCTSICSLYQLENYCN |
| Enzyme Length | 108 |
| Uniprot Accession Number | P01315 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (1); Disulfide bond (3); Erroneous initiation (1); Helix (5); Peptide (2); Propeptide (1); Signal peptide (1) |
| Keywords | 3D-structure;Carbohydrate metabolism;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;Glucose metabolism;Hormone;Reference proteome;Secreted;Signal |
| Interact With | Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000269|PubMed:5657063 |
| Structure 3D | Neutron diffraction (3); X-ray crystallography (39) |
| Cross Reference PDB | 1B17; 1B18; 1B19; 1B2A; 1B2B; 1B2C; 1B2D; 1B2E; 1B2F; 1B2G; 1DEI; 1IZA; 1IZB; 1M5A; 1MPJ; 1SDB; 1WAV; 1ZEI; 1ZNI; 2EFA; 2G4M; 2TCI; 2ZPP; 3FHP; 3GKY; 3INS; 3MTH; 3RTO; 3T2A; 4A7E; 4INS; 5D52; 5D53; 5D54; 5D5E; 5FB6; 5LIS; 6INS; 6Z7Z; 7AC4; 7INS; 9INS; |
| Mapped Pubmed ID | 12657786; 1272390; 1361949; 1504238; 17327674; 1856866; 18725203; 19770501; 19850922; 21542590; 22194335; 22505429; 23416304; 24389353; 26894538; 2695122; 27275143; 27599736; 33277949; 34473086; 7492558; 8760462; 9096331; 9708987; |
| Motif | |
| Gene Encoded By | |
| Mass | 11,672 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |