| IED ID | IndEnz0002003596 |
| Enzyme Type ID | protease003596 |
| Protein Name |
Gamma-terpinene synthase 1 EC 4.2.3.114 Alpha-terpinene synthase 1 EC 4.2.3.115 Terpene synthase 1 TvTPS1 |
| Gene Name | TPS1 |
| Organism | Thymus vulgaris (Thyme) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae asterids lamiids Lamiales Lamiaceae Nepetoideae Mentheae Thymus Thymus vulgaris (Thyme) |
| Enzyme Sequence | MRRSGNYQAPVWNNDFIQSFSTDKYKDEKFLKKKEELIAQVKVLLNTKMEAVKQLELIEDLRNLGLTYYFEDEFKKILTSIYNEHKGFKNEQVGDLYFTSLAFRLLRLHGFDVSEDVFNFFKNEDGSDFKASLGENTKDVLELYEASFLIRVGEVTLEQARVFSTKILEKKVEEGIKDEKLLAWIQHSLALPLHWRIQRLEARWFLDAYKARKDMNPIIYELGKIDFHIIQETQLQEVQEVSQWWTNTNLAEKLPFVRDRIVECYFWALGLFEPHEYGYQRKMAAIIITFVTIIDDVYDVYDTLDELQLFTDAIRKWDVESISTLPYYMQVCYLAVFTYASELAYDILKDQGFNSISYLQRSWLSLVEGFFQEAKWYYAGYTPTLAEYLENAKVSISSPTIISQVYFTLPNSTERTVVENVFGYHNILYLSGMILRLADDLGTTQFELKRGDVQKAIQCYMNDNNATEEEGTEHVKYLLREAWQEMNSAMADPDCPLSEDLVFAAANLGRTSQFIYLDGDGHGVQHSEIHNQMGGLIFEPYV |
| Enzyme Length | 542 |
| Uniprot Accession Number | A0A0M3Q1Q3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=(2E)-geranyl diphosphate = diphosphate + gamma-terpinene; Xref=Rhea:RHEA:32559, ChEBI:CHEBI:10577, ChEBI:CHEBI:33019, ChEBI:CHEBI:58057; EC=4.2.3.114; Evidence={ECO:0000269|PubMed:26750479};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32560; Evidence={ECO:0000269|PubMed:26750479}; CATALYTIC ACTIVITY: Reaction=(2E)-geranyl diphosphate = alpha-terpinene + diphosphate; Xref=Rhea:RHEA:32563, ChEBI:CHEBI:10334, ChEBI:CHEBI:33019, ChEBI:CHEBI:58057; EC=4.2.3.115; Evidence={ECO:0000250|UniProtKB:E2E2P0};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32564; Evidence={ECO:0000250|UniProtKB:E2E2P0}; |
| DNA Binding | |
| EC Number | 4.2.3.114; 4.2.3.115 |
| Enzyme Function | FUNCTION: Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents (PubMed:26750479). Monoterpene synthase which catalyzes the conversion of geranyl diphosphate (GPP) to gamma-terpinene and the minor products alpha-thujene, alpha-terpinene, myrcene, sabinene, (+)-R-limonene, alpha-pinene and alpha-phellandrene (PubMed:26750479). {ECO:0000269|PubMed:26750479}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. {ECO:0000269|PubMed:26750479}. |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (6); Motif (1); Mutagenesis (2); Region (2); Site (2) |
| Keywords | 3D-structure;Lyase;Magnesium;Manganese;Metal-binding |
| Interact With | |
| Induction | INDUCTION: Induced by jasmonic acid (MeJA), salicylic acid (SA) and UV-C irradiation. {ECO:0000269|PubMed:28365519}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 5C05; |
| Mapped Pubmed ID | - |
| Motif | MOTIF 295..299; /note=DDXXD motif; /evidence=ECO:0000250|UniProtKB:Q9X839 |
| Gene Encoded By | |
| Mass | 63,274 |
| Kinetics | |
| Metal Binding | METAL 295; /note=Manganese 1; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7; METAL 295; /note=Manganese 2; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7; METAL 299; /note=Manganese 1; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7; METAL 299; /note=Manganese 2; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7; METAL 439; /note=Manganese 3; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7; METAL 447; /note=Manganese 3; /evidence=ECO:0000250|UniProtKB:A0A1C9J6A7 |
| Rhea ID | RHEA:32559; RHEA:32560; RHEA:32563; RHEA:32564 |
| Cross Reference Brenda |