| IED ID |
IndEnz0002003622 |
| Enzyme Type ID |
protease003622 |
| Protein Name |
Helix-loop-helix protein hlh-12
|
| Gene Name |
hlh-12 mig-24 C28C12.8 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MAKKPRVTKLNTDRRSRANERERQRVSEMNGMFDVLLNLLPPSHFKTRLSRVQILREATSYIIRLHNFLIESSNSDIDAITVFPHIFNGERKSNKDAIRRPMKLKQGGGVAAFISRHELPPLQLPNPVIPILKPTSVPVWPQTNVYIAYF |
| Enzyme Length |
150 |
| Uniprot Accession Number |
Q18277 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor which binds the E box motif 5'-GCAGGTG-3' (PubMed:17588558). Involved in migration of the gonadal leader cells; distal tip cells (DTCs) in hermaphrodites, and linker cells in males (PubMed:25982859, PubMed:17588558). Positively regulates expression of alpha integrin ina-1 and ADAMTS protease gon-1 (PubMed:25982859, PubMed:17588558). {ECO:0000269|PubMed:17588558, ECO:0000269|PubMed:25982859}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Domain (1); Region (3) |
| Keywords |
DNA-binding;Nucleus;Reference proteome;Transcription;Transcription regulation |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12529635;
16507136;
16845399;
17090602;
17164286;
17704769;
19343510;
19564624;
19632181;
20308279;
22347378;
22560298;
22921415;
23800452;
25487147;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
17,270 |
| Kinetics |
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| Metal Binding |
|
| Rhea ID |
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| Cross Reference Brenda |
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