| IED ID | IndEnz0002003696 |
| Enzyme Type ID | protease003696 |
| Protein Name |
Chymotrypsin-like elastase family member 1 EC 3.4.21.36 Elastase-1 Pancreatic elastase 1 |
| Gene Name | CELA1 ELA1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWINNVIASN |
| Enzyme Length | 258 |
| Uniprot Accession Number | Q9UNI1 |
| Absorption | |
| Active Site | ACT_SITE 63; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 111; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 206; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.; EC=3.4.21.36; |
| DNA Binding | |
| EC Number | 3.4.21.36 |
| Enzyme Function | FUNCTION: Acts upon elastin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Erroneous gene model prediction (1); Glycosylation (2); Metal binding (3); Natural variant (5); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Calcium;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..8; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 19913121; 20346360; 20379614; 20628086; 23395568; 24622077; 24949484; 25319362; 26601880; 28604957; 29521945; 30054822; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,798 |
| Kinetics | |
| Metal Binding | METAL 77; /note=Calcium; /evidence=ECO:0000250; METAL 82; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 87; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.36; |