| IED ID | IndEnz0002003711 |
| Enzyme Type ID | protease003711 |
| Protein Name |
Non-toxic nonhemagglutinin type D NTNHA Botulinum neurotoxin type D non-toxic component |
| Gene Name | ntnha ntnh |
| Organism | Clostridium botulinum D phage (Clostridium botulinum D bacteriophage) |
| Taxonomic Lineage | Viruses Duplodnaviria Heunggongvirae Uroviricota Caudoviricetes Caudovirales Siphoviridae (phages with long non-contractile tails) unclassified Siphoviridae Clostridium botulinum D phage (Clostridium botulinum D bacteriophage) |
| Enzyme Sequence | MDINDDLNINSPVDNKNVVIVRARKTNTFFKAFKVAPNIWVAPERYYGEPLDIAEEYKLDGGIYDSNFLSQDSERENFLQAIITLLKRINNTISGKQLLSLISTAIPFPYGYVGGGYSSPNIFTFGKTPKSNKKLNSLVTSTIPFPFGGYRETNYIESQNNKNFYASNIVIFGPGSNIVENNVICYKKNDAENGMGTMAEILFQPLLTYKYNKFYIDPAMELTKCLIKSLYFLYGIKPSDDLVVPYRLRTELDNKQFSQLNIIDLLISGGVDLEFINTNPYWFTNSYFSNSIKMFEKYKNIYETEIEGNNAIGNDIKLRLKQKFQNSVQDIWNLNLNYFSKEFNSIIPDRFSNALKHFYRKQYYTMDYGDNYNINGFVNGQINTKLPLSDKNTNIISKPEKVVNLVNANNISLMKSNIYGDGLKGTTEDFYSTYKIPYNEEYEYRFNDSDNFPLNNISIEEVDSIPEIIDINPYKDNSDDLLFTQITSTTEEVITHTALPVNYLQAQIITNENFTLSSDFSKVVSSKDKSLVYSFLDNLMSYLETIKNDGPIDTDKKYYLWLKEVFKNYSFDINLTQEIDSSCGINEVVIWFGKALNILNTSNSFVEEYQNSGPISLISKKDNLSEPNIEIDDIPDSLLGLSFKDLNNKLYEIYSKNRVYFRKIYFNFLDQWWTEYYSQYFELICMAKQSILAQESVVKQIIQNKFTDLSKASIPPDTLKLIKETTEKTFIDLSNESQISMNRVDNFLNKASICVFVEDIYPKFISYMEKYINNINIKTREFIQRCTNINDNEKSILINSYTFKTIDFKFLNIQAIKNFFNSQVEQVMKEMLSPYQLLLFATRGPNSNIIEDISGKNTLIQYTESVELVYGVNGESLYLKSPNETVEFSNNFFTNGLTNNFTICFWLRFTGKDDDKTRLIGNKVNNCGWEIYFEDNGLVFEIIDSNGNQESVYLSNVINNNWYYISISVDRLKDQLLIFINDKNVANVSIEQILNIYSTNVISLVNKNNSIYVEELSVLDKPVASEEVIRNYFSYLDNSYIRDSSKSLLEYNKNYQLYNYVFPETSLYEVNDNNKSYLSLKNTDGINIPSVKFKLINIDESKGYVQKWDECIICVSDGTEKYLDISPENNRIQLVSSKDNAKKITVNTDLFRPDCITFSYNDKYFSLSLRDGDYNWMICNDNNKVPKGAHLWILKS |
| Enzyme Length | 1196 |
| Uniprot Accession Number | Q9LBR2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Assembles with botulinum neurotoxin type D (BoNT/D) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0. The non-toxic component is necessary to maintain toxicity. {ECO:0000250|UniProtKB:Q45914}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Region (3) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Secreted;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11713244, ECO:0000269|PubMed:17581814, ECO:0000269|PubMed:8569530}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 3VUO; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 138,455 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |