| IED ID | IndEnz0002003759 |
| Enzyme Type ID | protease003759 |
| Protein Name |
Extracellular metalloproteinase 4 EC 3.4.24.- Fungalysin MEP4 |
| Gene Name | MEP4 |
| Organism | Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
| Enzyme Sequence | MHGLMLAGLLALPLSVLGHPTESHSSGISRRAIDITSYRLPQISKYTKSDAVPKQDGESFTTSSTGNDNSSSGDYVTTATNWLKKTLPKATYRLVKDHYIGDSGIGHVHFRQTAHGIDIDNTDFNVNIGRDGKVFSFGNSFYDGEIPKANPMVKRDFSDPVNALHGAIQILNLPVTAKPENVKAKPVEGKENFKFEGTSGALSDPKAQLVYLQKDGGLVLSWKVETDVGDNWLLTYVDANKNDKVHSVVDYVSAAEYQVYPWGINDPTEGNRTTLHLPWLKTLSTDWHIDGKGWYSTTRGNNAIAQENPTGGPEYENNYRPKSPLFIFKYPYSKAMTPPSSYRDASITQLFYTTNVYHDVLYILGFNEKAGNFQINNWNKGGVGGDYAILNSQDGSGVNNANFATPPDGQPGRMRMYTWNASIPERDGCFEAGIVIHEYTHGVSNRLTGGPENSRCLAALESGGMGEGWSDFFATAIRLKPGDTRVTDYTMGEWASNRPNGIRKYRYSTSLTTNPHMYVDADGLTSVHAIGNIWASMLYELLWNLIDKHGKGDVTKIRPVLKNGVPTDGRHLAMKIVLDGMALQPCLPNFVQARDAILDADKNLTQGSNKCEIWKAFAKRGLGVGAVFNLSKRTGSNELPAGC |
| Enzyme Length | 643 |
| Uniprot Accession Number | Q8NIJ4 |
| Absorption | |
| Active Site | ACT_SITE 438; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Secreted metalloproteinase probably acting as a virulence factor. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Glycosylation (4); Metal binding (2); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Virulence;Zinc;Zymogen |
| Interact With | |
| Induction | INDUCTION: Expression is strongly increased during growth on protein-rich medium. Expressed at even higher levels when keratin is present in the protein-rich medium. {ECO:0000269|PubMed:19098130}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14766908}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 70,698 |
| Kinetics | |
| Metal Binding | METAL 437; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 441; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |