| IED ID | IndEnz0002003763 |
| Enzyme Type ID | protease003763 |
| Protein Name |
MPN domain-containing protein CG4751 EC 3.4.-.- |
| Gene Name | CG4751 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MENGVEHGVDESGENQVLSSSDGEGDCDGDGEVEGEVLQPPPPPPLQITNDCVGEGVQAEEGERAPATTGAVDVTPDPGPPPTDGAAPVAILEDNMCDKDVDSDAGDEDNDDETKENYEGFNGTGRTVTLQTLMAANVLQPGLGLMTIEYLGQKFVGDLLADGKIKSHETETIFLTPSAWAMHCKRIINPDKKSGCGWASVKYKGKKLDAYKNTYLRKCALQKETPLDDCELDAERKTDTPEIVVKRTVFAHNTVSNRNVVHDANMLIESVPFTSVGKLQPFLITVNSSALLLADFHCHLTVREVCGYLGGTWDMNTHTLSITKTYPCRSTRFDRQRAGEVERDIQKMMIQDQLLLVGWYHSHPKFQAEPTLRDCDAQLDYQIKMRGASDLTYTPCVSLIISPYYDENPTLESVVKCIWIVPPNENRQSMEYGRPMLMQYSVLPDKEIPEEVRSEIQLCVDYYSQYRSEMVKFRNIYNNDVTYNEKLKNTLYPKFPSKQSDKALWNWICAVLDCEQEDDFIPPKTIKIIDNDDLEVKEEDKPVVLMDLSGDVKINPPKEEQFSEAMGGLEDSGRKAEEESNAQAEQKASELKVMSLQEQLCMPSGLNMNPVRMLSPLATPNPTSLPPVLPNLGAPVLPATPSQLLPPQVPAVTAPPAITPAVTTSALTSALNASPRDSPITIQSNSASPAKFEVPVRASPSPAKSDTSSHASTSRTRNSPAPSPGKFSVSDIARNSPSITPNKYEAAAAALVPPAAACLPTANDLMAASLAQLAGQLPPNFLQGDLAALFQQQRKDYGSSSLNQLAAAAAKVGGSKQSNASASSGLNDPNVAAAVAAYSNSFNMPLPTGVGIGGSGNSNAHSSSKSKSERSSKSSSSSSSSNSSSTSNSYKTKLMKELDELKNDPLKMSELIRSPEYAALLLQQAEALGATTLGTLGFGSDYSYLTGAGLGVPAANALTGGQSSNSSSSKSSKSSPAAAAAAALSADYNNLIQASKLLGYDSYMQQSKQSNDLNAFLQQQMAVAAASIPPPPQTASSGSSNSSSSKKQQQLQQQQHQQQQQQQQQQAAAQADYTALLQTYTKLFDPNNQFAAAMSSNKHMAGAHNELSALLSSGVGVGGGASGGGSKQKQKDIQSDMLNQLLQLEKQDSEIKALLYRQNKAAADLDALFATPSGAVVGAGSSANAMKSGSSAGNSGVSGMSSPSSLSNQAAYYNALAQEKMQDYAAFFQQQHGKYGIPDPLSKTTLAANNMFMTPSALFKIQQESLSAMMMKPPKSTTPSSARTRESSASPALERLTPTKSASSGGSGGGGSNSNSGGKYNFSAVDLAISSVPSNTPSPAPSDGSSGSSHRRPSPDIGRLYGELAPPGALLGSGGVPKKRMEFASVADLAAPPPAKMPKNNMGDDILNLSHD |
| Enzyme Length | 1412 |
| Uniprot Accession Number | Q9VKJ1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Probable protease. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (1); Compositional bias (6); Domain (2); Metal binding (3); Modified residue (9); Region (8) |
| Keywords | Coiled coil;Hydrolase;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 699; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 701; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 705; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 719; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 723; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 728; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 1288; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 1290; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 1297; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:18327897 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12183637; 14605208; 20068067; 20220848; 20371351; 20813047; 21074052; 21447707; 22937016; 23071443; 23275879; 23899565; 25294943; 25312911; 25532219; 26173873; 26202798; 27172210; 29050293; 30592458; 31722958; 33988679; |
| Motif | |
| Gene Encoded By | |
| Mass | 149,953 |
| Kinetics | |
| Metal Binding | METAL 361; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 363; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 374; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |