| IED ID | IndEnz0002003764 |
| Enzyme Type ID | protease003764 |
| Protein Name |
Olfactomedin-like protein 3 Olfactomedin-noelin-tiarin factor 1 |
| Gene Name | olfml3 ont1 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MMAGIVACILLVFVTVITAQPQAVFLEYIQGRMGVLEERIAQWHDQSSRFSGELRDFKNQVLKMLENIEKERDSLRNEMENTNVRVNRLEREVDYIETQNPAPPCVEIDEKLSDHHGAKKKKKEKYQKITDCSDTISQVTAMKILKRFGSSAGLWTKDLAGNSDRIYVFDGAGNDTVYMYPRMKEFTLSSPTRKAAKIRLPFPWIGTGHIVYDGNLYYIRQDNEFQVIKFSLANKTIIDSAVLPIEQQVPVYGLSKFNYIDIVADEEGLWVIYATKENEKNICLAKLDPSSLSIEQMWDTPCPIENAESAFVVCGSLYVVYNTKLPSRSRIQCVFDVSGTISSENVPIVYFPKRYGSHSSMKYNPREKQIYAWDDGYQIIYKLNMKHRDELY |
| Enzyme Length | 392 |
| Uniprot Accession Number | B5MFE9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1. {ECO:0000269|PubMed:18775317}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (1); Disulfide bond (1); Domain (1); Erroneous initiation (1); Glycosylation (2); Sequence conflict (1); Signal peptide (1) |
| Keywords | Coiled coil;Developmental protein;Disulfide bond;Glycoprotein;Secreted;Signal |
| Interact With | P98070; Q91713; Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,110 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |