| IED ID | IndEnz0002003771 |
| Enzyme Type ID | protease003771 |
| Protein Name |
Napsin-A EC 3.4.23.- Aspartyl protease 4 ASP4 Asp 4 Napsin-1 TA01/TA02 |
| Gene Name | NAPSA NAP1 NAPA |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSPPPLLQPLLLLLPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQALDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARARTRGADLGWGETAQAQFPG |
| Enzyme Length | 420 |
| Uniprot Accession Number | O96009 |
| Absorption | |
| Active Site | ACT_SITE 96; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 283; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: May be involved in processing of pneumocyte surfactant precursors. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (3); Natural variant (2); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | Q5T7P3; Q5TA76 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12151090; 12698189; 13129928; 15161933; 1568474; 18195689; 18216060; 19740516; 20830690; 21164283; 21464700; 21717589; 21838611; 22156835; 22198009; 22288963; 22418245; 22495379; 22914608; 23194051; 23333608; 23355200; 23503645; 23681073; 23899066; 24191930; 24331839; 24479710; 24721826; 2515193; 25389337; 25521803; 25551297; 2587265; 25889632; 25971546; 25982999; 26339401; 26400099; 26447895; 26469326; 26696549; 26710975; 26808134; 26842346; 26945446; 27045515; 27412420; 29845258; 29901522; 29956857; 31361605; 31953311; 32270298; 32561332; 33247694; 3366248; |
| Motif | |
| Gene Encoded By | |
| Mass | 45,387 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.23.B1; |