| IED ID | IndEnz0002003773 |
| Enzyme Type ID | protease003773 |
| Protein Name |
Neprilysin-1 EC 3.4.24.- |
| Gene Name | |
| Organism | Trittame loki (Brush-footed trapdoor spider) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Araneae (spiders) Mygalomorphae (mygalomorph spiders) Barychelidae Trittame Trittame loki (Brush-footed trapdoor spider) |
| Enzyme Sequence | MAVALLVALCVVSSRMALPSEAVPFYRQDSEVCNSPVCQKAAQTLLESMDTSVDPCQDFYQYACGEWIRKHPIPEEKFRISPLDALYDNVLDTVAEILKNATSENHATSVLKSANYFQACMDAEARETQGVEPLKNLLTSLGGWPMATPGWSGANYHWQTQVATVTRNLGIRPIIDVFVDADANRTSQHIINLDQADFGLGRNQLINLTSSSRTQEIVAGYRNYIIASAKLLNPNADDIQLANDADEIIQFESTLAQFSTPPEERRDASSWYHKMTVAEVQTVTENTYFQWTEFLNTVLKEFPQVMPETEVILYERDYTKNVLKLAHETNPRILANYIGWIVLMKEGYHTTRQFRENKFQFEKVQIGIEKEEKLERVCTDHTIGLLGYAVGRLYVDKFFTEEEKQDIDELVENIRSAYKSTLRNNTWMDHVTRNKAIDKLEAMINKMAYPTWIKNDNELNEYYRSVPAINRDEFFSSLLKVTKVVKAIQLGKWNKPTDRIKDWITTPAVVNAFYSPDSNSMSFPAGILNWPLYQYGTSPALNYGAIGAIIGHEMSHGFDDQGGQTDPEGNLVDWWLEETKAKFNQKADCFRKQYSSYLEPTTNMHLNGNNTVGENIADNGAVRNAFIAYKMHLLHSQNNHVMRKKTLPGLSATAEQLFFLGYSTMWCGAERKESLEWSIQYDSHTPSEFRAVVPLTNSRSFAEAFGCASGTPMNPTHKCLLW |
| Enzyme Length | 722 |
| Uniprot Accession Number | W4VS99 |
| Absorption | |
| Active Site | ACT_SITE 553; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; ACT_SITE 618; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (5); Metal binding (3); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Contains 5 disulfide bonds. {ECO:0000305}. |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 82,056 |
| Kinetics | |
| Metal Binding | METAL 552; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 556; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 614; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Rhea ID | |
| Cross Reference Brenda |