| IED ID | IndEnz0002003776 |
| Enzyme Type ID | protease003776 |
| Protein Name |
Endonuclease G, mitochondrial Endo G EC 3.1.30.- Ced-3 protease suppressor 6 |
| Gene Name | cps-6 C41D11.8 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MIGKVAGTAAIAGISFLAGKYSNDDLPIFRNVQSATNVPMNQIQVSEPMTVKPASLNADAMGPSRSAEIMKHGYPGFTNVRTYEDFVLSYDYKTRTAHWVCEHLTPERLKHAEGVDRKLCEFKPDITFPQKFLSQNTDYKCSGFDRGHLAAAGNHRKSQLAVDQTFYLSNMSPQVGRGFNRDKWNDLEMHCRRVAKKMINSYIITGPLYLPKLEGDGKKYIKYQVIGDNNVAVPTHFFKVALFEVTPGKFELESYILPNAVIEDTVEISKFHVPLDAVERSAGLEIFARLDPKSIVKENGAKKGGLLW |
| Enzyme Length | 308 |
| Uniprot Accession Number | Q95NM6 |
| Absorption | |
| Active Site | ACT_SITE 148; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10047 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.30.- |
| Enzyme Function | FUNCTION: Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. {ECO:0000269|PubMed:11452313}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (11); Chain (1); Helix (12); Metal binding (1); Transit peptide (1); Turn (6) |
| Keywords | 3D-structure;Apoptosis;Endonuclease;Hydrolase;Magnesium;Metal-binding;Mitochondrion;Nuclease;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11452313}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 3S5B; 4QN0; 5GKC; 5GKP; |
| Mapped Pubmed ID | 12446902; 12718884; 12840007; 20223951; 20382228; 21085631; 21177967; 21367940; 22223640; 22560298; 23800452; 25487147; 27338704; 27346342; 27738134; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,511 |
| Kinetics | |
| Metal Binding | METAL 180; /note=Magnesium; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |