| IED ID | IndEnz0002003792 |
| Enzyme Type ID | protease003792 |
| Protein Name |
Putative endoplasmic reticulum metallopeptidase 1 EC 3.4.-.- FXNA-like protease |
| Gene Name | erm1 SPCC1259.02c |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MVLVCASSSKCKRNTFLQLAMVLFAVVMARIALYFHNHLDEPLVDPYDANGNPQFSEANALKHVIHLSDDIGYRILGTIEQERAREYIMNEVLALQKQLQDGPNADIHQMEVSLESGDGAHRFDFMNKYVIKKYQNLKNIVVRLSNGTEACKEEAVLINAHVDSTLPSPGATDDALAVAILLEAIRIFISRPVPLTHSIVFLFNDAEESLQDASHMFITQSPLRDTIKCVVNLEACGTTGSEILFQATSNEMIKAYSHVPHPFGTVLADDVFRTGLILSDTDFRQFVQYGNLTGLDMAVVKNSYLYHTKKDLAPYISPGTPQNFGENILAILTYLVSPEADLNNMKSSGTVYFSVFNSLFFMYSKLTSKILNTLVGGLGILLTLRGSEGSFTVALIAQVISIAGIFVIPNIWAYILGNVLDCGMSWFRNEYWPLFIYLPAIFASLFFTESLFKRSEHLALRATIFIFSLLTFIPLPSAYLFTIIDFFMVFALFLNDKILAKPGTVHPLTYFIGSIGAMTVGFESAINLLEIFVPLTGRIGTDKVADNVVATVCVCGFNIYFPLMSPWIQRFRSRCCFRLGLLFSIFVVGFSSFILAKQDTYYDSLHPRRIFVQRMENITSNEVSLHIASADSAPGFDKLSSDLSSLLTDEPVVKTEMDDWNSDWDTVYPFSQFLGSYRIPLNDTVDVTTLPSIKFSNKVVKDNVVNVTVTVEHPGLIWTVVSFDADVLSWSLPEVPSTVRRHHVREVSAYGLDSYSFNMSYLEAPIYFDFVGVDGVGHYPSKASEGRDRASIQLCEKLTNDYLPDWTDTLCIGVVSGNFKLE |
| Enzyme Length | 822 |
| Uniprot Accession Number | O94702 |
| Absorption | |
| Active Site | ACT_SITE 207; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (6); Metal binding (6); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20473289; 22633491; 23697806; 34250083; |
| Motif | |
| Gene Encoded By | |
| Mass | 91,843 |
| Kinetics | |
| Metal Binding | METAL 161; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 173; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 173; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 208; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 234; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 307; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |