| IED ID |
IndEnz0002003793 |
| Enzyme Type ID |
protease003793 |
| Protein Name |
Septation ring formation regulator EzrA
|
| Gene Name |
ezrA ytwP BSU29610 |
| Organism |
Bacillus subtilis (strain 168) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus subtilis group
Bacillus subtilis
Bacillus subtilis subsp. subtilis
Bacillus subtilis (strain 168)
|
| Enzyme Sequence |
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA |
| Enzyme Length |
562 |
| Uniprot Accession Number |
O34894 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization. {ECO:0000269|PubMed:10449747}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Coiled coil (4); Topological domain (2); Transmembrane (1) |
| Keywords |
3D-structure;Cell cycle;Cell division;Cell membrane;Coiled coil;Membrane;Reference proteome;Septation;Transmembrane;Transmembrane helix |
| Interact With |
P28264; P17865 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488, ECO:0000305|PubMed:10449747}; Single-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488}; Single-pass membrane protein {ECO:0000255}. Note=Cell membrane associated, also colocalizes with FtsZ to the nascent septal site (PubMed:10449747). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:22882210, PubMed:24222488). {ECO:0000269|PubMed:10449747, ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: May be degraded by FtsH protease. {ECO:0000305|PubMed:24222488}. |
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
4UXV;
|
| Mapped Pubmed ID |
16796675;
17662947;
18363795;
21630458;
25403286;
|
| Motif |
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| Gene Encoded By |
|
| Mass |
64,996 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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