| IED ID | IndEnz0002003802 |
| Enzyme Type ID | protease003802 |
| Protein Name |
Gag polyprotein Pr53Gag Cleaved into: Matrix protein p16 MA ; p2L; Capsid protein p26 CA ; p3; Nucleocapsid protein p13 NC ; p2 |
| Gene Name | gag |
| Organism | Bovine immunodeficiency virus (strain R29) (BIV) (Bovine immunodeficiency-like virus) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Lentivirus Bovine immunodeficiency virus Bovine immunodeficiency virus (strain R29) (BIV) (Bovine immunodeficiency-like virus) |
| Enzyme Sequence | MKRRELEKKLRKVRVTPQQDKYYTIGNLQWAIRMINLMGIKCVCDEECSAAEVALIITQFSALDLENSPIRGKEEVAIKNTLKVFWSLLAGYKPESTETALGYWEAFTYREREARADKEGEIKSIYPSLTQNTQNKKQTSNQTNTQSLPAITTQDGTPRFDPDLMKQLKIWSDATERNGVDLHAVNILGVITANLVQEEIKLLLNSTPKWRLDVQLIESKVREKENAHRTWKQHHPEAPKTDEIIGKGLSSAEQATLISVECRETFRQWVLQAAMEVAQAKHATPGPINIHQGPKEPYTDFINRLVAALEGMAAPETTKEYLLQHLSIDHANEDCQSILRPLGPNTPMEKKLEACRVVGSQKSKMQFLVAAMKEMGIQSPIPAVLPHTPEAYASQTSGPEDGRRCYGCGKTGHLKRNCKQQKCYHCGKPGHQARNCRSKNGKCSSAPYGQRSQPQNNFHQSNMSSVTPSAPPLILD |
| Enzyme Length | 476 |
| Uniprot Accession Number | P19558 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Matrix protein p16 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane. {ECO:0000250}.; FUNCTION: Capsid protein p26 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Interaction between incoming particle-associated Gag proteins and host dynein allows intracellular microtubule-dependent virus transport toward the perinuclear region, prior to nucleus translocation and integration into host genome. {ECO:0000269|PubMed:20148896}.; FUNCTION: Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (5); Compositional bias (2); Motif (1); Natural variant (7); Peptide (2); Region (2); Site (4); Zinc finger (2) |
| Keywords | Capsid protein;Cytoplasmic inwards viral transport;Host-virus interaction;Metal-binding;Microtubular inwards viral transport;Repeat;Ribosomal frameshifting;Viral budding;Viral budding via the host ESCRT complexes;Viral matrix protein;Viral nucleoprotein;Viral release from host cell;Virion;Virion maturation;Virus entry into host cell;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Matrix protein p16]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Capsid protein p26]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p13]: Virion {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 468..471; /note=PTAP/PSAP motif |
| Gene Encoded By | |
| Mass | 53,440 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |