| IED ID | IndEnz0002003808 |
| Enzyme Type ID | protease003808 |
| Protein Name |
GPI-anchor transamidase GPI transamidase EC 3.-.-.- |
| Gene Name | GPI8 YDR331W D9798.2 |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MRIAMHLPLLLLYIFLLPLSGANNTDAAHEVIATNTNNWAVLVSTSRFWFNYRHMANVLSMYRTVKRLGIPDSQIILMLSDDVACNSRNLFPGSVFNNKDHAIDLYGDSVEVDYRGYEVTVENFIRLLTDRWTEDHPKSKRLLTDENSNIFIYMTGHGGDDFLKFQDAEEIASEDIADAFQQMYEKKRYNEIFFMIDTCQANTMYSKFYSPNILAVGSSEMDESSYSHHSDVEIGVAVIDRFTYYCLDFLEQIDKNSTLTLQDLFDSFTFEKIHSHVGVRTDLFDRNPSEVLITDFFANVQNVIPDDSKPLSVSHYHHYKDHIDTAQYELNNNVLDLALETYRKNNQSSKIEKKIKDIKSTSVLDVDIDSNECFFTSFKQSATIILALIVTILWFMLRGNTAKATYDLYTN |
| Enzyme Length | 411 |
| Uniprot Accession Number | P49018 |
| Absorption | |
| Active Site | ACT_SITE 157; ACT_SITE 199 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.-.-.- |
| Enzyme Function | FUNCTION: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (1); Glycosylation (2); Mutagenesis (6); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;Endoplasmic reticulum;GPI-anchor biosynthesis;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Thiol protease;Transmembrane;Transmembrane helix |
| Interact With | P39012; P38875; Q04080 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: The disulfide bond between GPI8 and GPI16 is important for normal enzyme activity. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11102867; 11283351; 11287675; 11805826; 15075373; 15939668; 16093310; 16429126; 16785205; 16859984; 17233591; 17361015; 17475206; 18467557; 19536198; 19883648; 19891730; 21134462; 23135325; 23951384; 28893510; 7559756; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,402 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |