| IED ID | IndEnz0002003817 |
| Enzyme Type ID | protease003817 |
| Protein Name |
Hepatocyte growth factor Hepatopoietin-A Scatter factor SF Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain |
| Gene Name | Hgf |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MMWGTKLLPVLLLQHVLLHLLLLHVAIPYAEGQKKRRNTLHEFKKSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLDPDTPWEYCAIKTCAHSAVNETDVPMETTECIQGQGEGYRGTSNTIWNGIPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDCYRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNKNYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTGLINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL |
| Enzyme Length | 728 |
| Uniprot Accession Number | Q08048 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269|PubMed:20624990}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Beta strand (15); Chain (2); Disulfide bond (19); Domain (6); Erroneous initiation (1); Glycosylation (4); Helix (4); Modified residue (1); Sequence conflict (8); Signal peptide (1); Turn (5) |
| Keywords | 3D-structure;Alternative splicing;Direct protein sequencing;Disulfide bond;Glycoprotein;Growth factor;Kringle;Pyrrolidone carboxylic acid;Reference proteome;Repeat;Serine protease homolog;Signal |
| Interact With | P08581 |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 33; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000250|UniProtKB:P14210 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..32; /evidence=ECO:0000250 |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 2QJ4; 3HMR; 4IUA; |
| Mapped Pubmed ID | 10064822; 10079225; 10352021; 10364163; 10551403; 10588868; 10625667; 10641789; 10652269; 10688652; 10704889; 10725250; 10727259; 10842060; 10843805; 10888866; 10951502; 11032833; 11061428; 11248243; 11310823; 11343646; 11375907; 11707776; 11723058; 11746958; 11761336; 11784715; 11809759; 11836782; 11896611; 11948403; 12115601; 12130561; 12193542; 12193555; 12351166; 12368906; 12397180; 12466851; 12482598; 12542542; 12670907; 12702649; 12878170; 12915117; 1385703; 1406687; 14500721; 14517989; 14550779; 14576199; 14607778; 14623241; 14625309; 14681479; 14694163; 14759494; 15072590; 15221943; 15261829; 15314156; 1535333; 15383179; 15555922; 15576826; 15841179; 15856015; 16079293; 16103912; 16141072; 16177122; 16247031; 16340242; 16380478; 16400035; 16403606; 16424394; 16476577; 16513678; 16602821; 16648972; 16651617; 16840775; 16877364; 16880525; 17068118; 17170214; 17203235; 17215404; 17241389; 17258200; 17412827; 17561000; 17583691; 17688880; 17699753; 17702746; 17761834; 17901400; 17923692; 17976157; 18032545; 18362143; 18395096; 18495663; 18504429; 18524894; 18628208; 18697905; 18820214; 18829539; 18922968; 18973760; 18988920; 19020551; 19071214; 19098908; 19234748; 19249600; 19330341; 19393645; 19448157; 19470725; 19576567; 19812386; 19853659; 20040596; 20060823; 20147731; 20332205; 20375988; 20382450; 20506405; 20508974; 20596656; 20639480; 20649939; 20843830; 20852387; 20934536; 21068842; 21072211; 21094172; 21148681; 21187969; 21209281; 21292498; 21293003; 21443522; 21554929; 21595927; 21666233; 21683144; 21703184; 21784852; 21940662; 22001117; 22035642; 22095660; 22245998; 22287599; 22318499; 22427375; 22535512; 22627288; 22682244; 22740630; 22987640; 22996389; 23024263; 23041440; 23064365; 23070814; 23077169; 23224784; 23229794; 23233163; 23293024; 23376422; 23459311; 23485708; 23527275; 23548689; 23560074; 23627689; 23722408; 23723997; 23773083; 23840657; 23886856; 23922381; 23934123; 23951403; 23994610; 24089510; 24223113; 24224701; 24246674; 24302003; 24349415; 24469707; 24569592; 24618323; 24634221; 24685580; 24692544; 24811579; 24865428; 24959005; 25114100; 25116473; 25362352; 25503558; 25510828; 25521737; 25571972; 25586556; 25905717; 25906153; 25938594; 26001768; 26165517; 26275053; 26290232; 26393505; 26551462; 26728565; 26739889; 26764350; 26818605; 26875548; 27030285; 27109105; 27143995; 27388243; 27488639; 27779646; 28218627; 28270618; 28429746; 28542142; 28758209; 28838957; 28855398; 28864680; 28969681; 29040876; 29436622; 29771943; 29928062; 30022023; 30066918; 30103949; 30242894; 30401749; 30627913; 30861238; 31115492; 31212972; 31221639; 31338035; 31535973; 31972251; 32152201; 32204446; 32258116; 32522231; 32539223; 32983173; 33455972; 33635004; 33930309; 7474919; 7490100; 7559778; 7651534; 7822413; 7851897; 7854452; 7854453; 7929565; 7935420; 7988745; 8034747; 8039703; 8071312; 8138271; 8179615; 8197126; 8200486; 8307976; 8408200; 8620851; 8631159; 8633043; 8635233; 8650184; 8681797; 8791524; 8824331; 8930401; 8982163; 9012848; 9166406; 9203584; 9362368; 9367820; 9417075; 9474750; 9540971; 9576745; 9620689; |
| Motif | |
| Gene Encoded By | |
| Mass | 82,945 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |