| IED ID | IndEnz0002003876 |
| Enzyme Type ID | protease003876 |
| Protein Name |
Metacaspase-1 AtMC1 EC 3.4.22.- Metacaspase 1b AtMCP1b Protein LSD ONE LIKE 3 |
| Gene Name | AMC1 LOL3 MCP1B At1g02170 T7I23.17 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MYPPPPSSIYAPPMLVNCSGCRTPLQLPSGARSIRCALCQAVTHIADPRTAPPPQPSSAPSPPPQIHAPPGQLPHPHGRKRAVICGISYRFSRHELKGCINDAKCMRHLLINKFKFSPDSILMLTEEETDPYRIPTKQNMRMALYWLVQGCTAGDSLVFHYSGHGSRQRNYNGDEVDGYDETLCPLDFETQGMIVDDEINATIVRPLPHGVKLHSIIDACHSGTVLDLPFLCRMNRAGQYVWEDHRPRSGLWKGTAGGEAISISGCDDDQTSADTSALSKITSTGAMTFCFIQAIERSAQGTTYGSLLNSMRTTIRNTGNDGGGSGGVVTTVLSMLLTGGSAIGGLRQEPQLTACQTFDVYAKPFTL |
| Enzyme Length | 367 |
| Uniprot Accession Number | Q7XJE6 |
| Absorption | |
| Active Site | ACT_SITE 164; /evidence=ECO:0000250; ACT_SITE 220 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Acts as a positive regulator of cell death. Required for both oxidative stress cell death response and hypersensitive cell death response mediated by immune response. {ECO:0000269|PubMed:15691845, ECO:0000269|PubMed:21097903}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Erroneous gene model prediction (1); Mutagenesis (1); Region (1) |
| Keywords | Autocatalytic cleavage;Hydrolase;Plant defense;Protease;Reference proteome;Thiol protease |
| Interact With | P94077 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: Proteolytically processed; by an autocatalytic mechanism. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12732715; 14576160; 18775970; 23633962; 24786830; 28157265; |
| Motif | |
| Gene Encoded By | |
| Mass | 39,792 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |