| IED ID | IndEnz0002003934 |
| Enzyme Type ID | protease003934 |
| Protein Name |
Cathepsin 8 EC 3.4.22.- Cathepsin 2 |
| Gene Name | Cts8 Cts2 Epcs68 Epcs70 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MGPAVLLAILCLGVAEVTQSSDPSLDSEWQEWKRKFNKNYSMEEEGQKRAVWEENMKLVKQHNIEYDQGKKNFTMDVNAFGDMTGEEYRKMLTDIPVPNFRKKKSIHQPIAGYLPKFVDWRKRGCVTPVKNQGTCNSCWAFSAAGAIEGQMFRKTGKLVPLSTQNLVDCSRLEGNFGCFKGSTFLALKYVWKNRGLEAESTYPYKGTDGHCRYHPERSAARITSFSFVSNSEKDLMRAVATIGPISVGIDARHKSFRLYREGIYYEPKCSSNIINHSVLVVGYGYEGKESDGNKYWLIKNSHGEQWGMNGYMKLARGRNNHCGIASYAVYPRV |
| Enzyme Length | 333 |
| Uniprot Accession Number | Q9JI81 |
| Absorption | |
| Active Site | ACT_SITE 138; /evidence=ECO:0000250|UniProtKB:O60911; ACT_SITE 276; /evidence=ECO:0000250|UniProtKB:O60911; ACT_SITE 300; /evidence=ECO:0000250|UniProtKB:O60911 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Probable protease (By similarity). In placenta, plays a role in promoting giant cell differentiation (PubMed:18776147). Also plays a role in placental spiral artery remodeling by direct degradation of smooth muscle alpha-actin (PubMed:18776147). {ECO:0000250|UniProtKB:O60911, ECO:0000269|PubMed:18776147}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (2); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Disulfide bond;Endosome;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Secreted;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18776147}. Lysosome {ECO:0000269|PubMed:18776147}. Endosome {ECO:0000269|PubMed:18776147}. Note=Localizes to the cytoplasm with a punctate staining pattern indicative of a predominant lysosomal and endosomal localization. {ECO:0000269|PubMed:18776147}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 16602821; 21119013; 22967998; 22987638; 34140513; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,803 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |