| IED ID | IndEnz0002003937 |
| Enzyme Type ID | protease003937 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase calypso EC 3.4.19.12 BAP1 homolog |
| Gene Name | calypso GH22997 |
| Organism | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Hawaiian Drosophila picture wing clade grimshawi clade grimshawi group grimshawi subgroup Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
| Enzyme Sequence | MSVAGGSISTAAGNAGKNNALPMAQLADGWLELESDPGLFTLLLEDFGCHDVQVEEVYDLQKPIESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGETLGRLKAHTKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVASCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHGCWEEHEDWTDKFRRVMAERLGIATGEQDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTLQKLLKADEQGERDEQQRPDTPTTLLEPSAFTARDLQSLLKNLDTEIAINEQHLADENDRRQMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKIANRLNRQTNAATAAANAANTNVAGTNAAGSKSQQQQQQTQQQPQQTQTAKNGKSPGKTPGRRRKGRNKCRKRK |
| Enzyme Length | 462 |
| Uniprot Accession Number | B4JW98 |
| Absorption | |
| Active Site | ACT_SITE 115; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 197; /note=Proton donor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Region (1); Site (1) |
| Keywords | Chromatin regulator;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to PcG response elements (PREs). {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,491 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |