| IED ID | IndEnz0002003949 |
| Enzyme Type ID | protease003949 |
| Protein Name |
Protein DDI1 homolog 1 EC 3.4.23.- |
| Gene Name | DDI1 QtsA-15268 QtsA-17104 |
| Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Enzyme Sequence | MLITVYCVRRDLSEATFSLQVSPDFELRNFKVLCEAESRVPAEEIQIIHMERLLIEDHCSLGSYGLKDGDVVVLLQKDNVGPRAPGRAPNQPRIDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSHGLASGETVGVPQGLGSPGLIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMAQQREKALREQERLHLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVNGKDESSDKEITHSVMDSGRKEH |
| Enzyme Length | 396 |
| Uniprot Accession Number | Q95JI3 |
| Absorption | |
| Active Site | ACT_SITE 260; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:Q8WTU0}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (1); Region (2); Sequence conflict (1) |
| Keywords | Aspartyl protease;Hydrolase;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,998 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |