IED Industry Enzyme Database

Detail Information for IndEnz0002003959
IED ID IndEnz0002003959
Enzyme Type ID protease003959
Protein Name Fibrinogen beta chain
Cleaved into: Fibrinopeptide B; Fibrinogen beta chain
Gene Name FGB
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
Enzyme Length 491
Uniprot Accession Number P02675
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (26); Chain (1); Coiled coil (1); Compositional bias (1); Disulfide bond (8); Domain (1); Glycosylation (1); Helix (13); Modified residue (1); Natural variant (17); Peptide (1); Region (2); Sequence caution (1); Sequence conflict (7); Signal peptide (1); Site (4); Turn (4)
Keywords 3D-structure;Adaptive immunity;Blood coagulation;Coiled coil;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Hemostasis;Immunity;Innate immunity;Pyrrolidone carboxylic acid;Reference proteome;Secreted;Signal
Interact With P27958
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
Modified Residue MOD_RES 31; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:420779
Post Translational Modification PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. {ECO:0000269|PubMed:2143188}.
Signal Peptide SIGNAL 1..30; /evidence="ECO:0000269|PubMed:420779, ECO:0000269|PubMed:936108, ECO:0000269|Ref.11, ECO:0000269|Ref.13"
Structure 3D X-ray crystallography (40)
Cross Reference PDB 1FZA; 1FZB; 1FZC; 1FZE; 1FZF; 1FZG; 1LT9; 1LTJ; 1N86; 1N8E; 1RE3; 1RE4; 1RF0; 1RF1; 2A45; 2FFD; 2H43; 2HLO; 2HOD; 2HPC; 2OYH; 2OYI; 2Q9I; 2XNX; 2XNY; 2Z4E; 3BVH; 3E1I; 3GHG; 3H32; 3HUS; 6ATZ; 6BIJ; 6BIL; 6V0Y; 6V13; 6V15; 6V18; 6V19; 6V1A;
Mapped Pubmed ID 10209122; 10409742; 10438935; 10446041; 10543983; 10605720; 10725339; 10777559; 10891492; 11027931; 11054085; 11293402; 11296154; 11476890; 11509636; 11546832; 11714857; 11728146; 11798781; 11836675; 11858186; 11877019; 11940334; 11960013; 12005431; 12048138; 12068308; 12082590; 12082592; 12122980; 12138165; 12140561; 12141403; 12151156; 12161363; 12297423; 12356313; 12393540; 12406024; 12447441; 12447442; 12473660; 12501189; 12511408; 12514663; 12518110; 12578626; 12585966; 12615788; 12616980; 12617173; 12637671; 12637691; 12640026; 12710752; 12716802; 12724322; 12747593; 12832465; 12871600; 12878203; 12893758; 12899665; 14618197; 14625308; 14629463; 14629469; 14636584; 14652632; 14669221; 14691567; 14706682; 14746139; 14754902; 14963283; 14970219; 14978285; 14992584; 14992585; 15035987; 15076187; 15091001; 15104216; 15157149; 15170397; 15192836; 15213870; 15217804; 15300640; 15346842; 15520807; 15543157; 15575509; 15583729; 15608011; 15630448; 15631828; 15671034; 15709716; 15735811; 15735812; 15737987; 15793786; 15795538; 15795540; 15842357; 15857159; 15939070; 15944945; 15968394; 15983960; 16005629; 16024789; 16040750; 16049588; 16080811; 16086292; 16115959; 16135787; 16144795; 16157382; 16195396; 16215953; 16239428; 16324093; 16353042; 16364920; 16409729; 16420563; 16439361; 16443328; 16466010; 16489740; 16525568; 16525569; 16533041; 16567932; 16581250; 16601848; 16604498; 16611940; 16614319; 16635210; 16689770; 16697386; 16706972; 16750002; 16767673; 16776623; 16879721; 16899909; 16919435; 16928957; 16938111; 16940416; 16953282; 17003923; 17111197; 17115186; 17115691; 17116333; 17126309; 17141195; 17160939; 1722201; 17230042; 17263791; 17264952; 17339034; 17411074; 17414213; 17469143; 17485511; 17496912; 17497226; 17563371; 17582472; 17591786; 17603482; 17603483; 17637253; 17688324; 17726518; 17849064; 17878161; 17878374; 17890055; 17893200; 17925485; 17951283; 17994314; 18000621; 18057060; 18070880; 18070982; 18173921; 18188987; 18202324; 18253477; 18278190; 18284606; 18331453; 18334738; 18434720; 18438411; 18503143; 18511872; 18513389; 18562239; 18642883; 18669862; 18683729; 18685811; 18692471; 1871708; 18726528; 18772067; 18818200; 18829464; 18836720; 18841297; 18842294; 18848323; 18853456; 18927546; 18930220; 18936436; 18974108; 18974842; 18977990; 18982866; 19056482; 19072566; 19075185; 19091303; 19131662; 19136375; 19143925; 19190816; 19219045; 19224918; 19227305; 19229055; 19238444; 19242111; 19264644; 19272152; 19279408; 19332210; 19352213; 19395327; 19404555; 19409601; 19420105; 19420351; 19431272; 19498957; 19506249; 19508823; 19559392; 19560472; 19578796; 19588915; 19592493; 19592497; 19593947; 19650644; 19682239; 19750100; 19811441; 19860767; 19892918; 19899640; 19906129; 19913121; 19923980; 19933846; 19948975; 19954614; 19956635; 20031576; 20031577; 20036902; 20051843; 20052757; 20059469; 20064497; 20075509; 20078877; 20079495; 20082208; 20128871; 20130576; 20135074; 20141835; 20162731; 20167083; 20179705; 20237496; 20360068; 20376805; 20425806; 20452482; 20485341; 20526349; 20533267; 20535834; 20536507; 20538554; 20619835; 20628086; 20637145; 20673868; 20709368; 20858867; 20873219; 20966070; 20978265; 21034162; 21054877; 21098282; 21122273; 21160146; 21241403; 21258858; 21296900; 21316837; 21420681; 21424530; 21475196; 21499712; 21606490; 21713329; 21725578; 21779496; 21900206; 21911577; 21988832; 22028648; 22053176; 22177953; 22273812; 22293628; 22386478; 22454496; 22489912; 22510884; 22552295; 22569528; 22575419; 22642105; 22745804; 22826437; 22836683; 22889670; 23056168; 23061815; 23129316; 23238100; 23300094; 23352452; 23583981; 23613522; 23614898; 23640497; 23650004; 23667175; 23852822; 23875798; 23877568; 23931975; 23934108; 23958299; 23969696; 24040290; 24121058; 24135138; 24136289; 24202393; 24316379; 24345920; 24366241; 24448059; 24466284; 24560896; 24651010; 24720800; 24746704; 24803720; 24937142; 24957141; 24957944; 25083866; 25195011; 25204086; 25204415; 25280629; 25313996; 25384698; 25398500; 25413489; 25435214; 25555432; 25809477; 25867317; 25890854; 25896470; 25907612; 25981141; 26006300; 26011420; 26077345; 26308135; 26317125; 26499778; 26628300; 27028649; 27044366; 27090576; 27150313; 27164460; 27227380; 27231021; 2742826; 27553289; 27738342; 27760719; 27812779; 27824214; 27834463; 27929198; 28039323; 28064398; 28306188; 28350862; 28437098; 28603947; 28621233; 2866798; 28801345; 28939558; 29134563; 29165755; 29235504; 29240685; 29286337; 29317506; 29467321; 29688408; 29748775; 30034615; 30039577; 30503677; 30794926; 30838756; 31295712; 31354890; 31713292; 31770277; 32126779; 32239963; 32286477; 32289806; 32472113; 32562089; 32610551; 3287375; 32877852; 33322044; 33863750; 34061326; 34460979; 6457647; 7356959; 7513017; 7565670; 7565795; 7731720; 7749821; 7929275; 7935411; 7997267; 8051079; 8157000; 8467233; 8565160; 8621540; 8649368; 8837778; 9001796; 9020159; 9351824; 9430229; 9437197; 9514419; 9566877; 9690809; 9851811; 9858547;
Motif
Gene Encoded By
Mass 55,928
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda